上海交通大学学报(医学版)

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遗忘型轻度认知损害患者基于低频振幅的静息态功能磁共振成像研究

席 芊1,赵小虎1,王培军1,郭起浩2,贺 永3   

  1. 1.同济大学附属同济医院医学影像科, 上海 200065; 2.复旦大学附属华山医院神经内科, 上海 200040; 3.北京师范大学 认知神经与学习国家重点实验室, 北京 100875
  • 出版日期:2014-08-28 发布日期:2014-09-02
  • 通讯作者: 王培军, 电子信箱: tongjipjwang@vip.sina.com。
  • 作者简介:席 芊(1978—), 男, 副主任医师, 博士, 硕士生导师; 电子信箱: 96125007@sina.com。
  • 基金资助:

    国家自然科学基金(81171297, 81301200);上海市科委科研项目(11JC1412000)

Study on resting state functional magnetic resonance imaging based on amplitude of low-frequency fluctuation for patients with amnestic mild cognitive impairment

XI Qian1, ZHAO Xiao-hu1, WANG Pei-jun1, GUO Qi-hao2, HE Yong3   

  1. 1.Department of Radiology, Tongji Hospital, Tongji University, Shanghai 200065, China; 2.Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China; 3.State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
  • Online:2014-08-28 Published:2014-09-02
  • Supported by:

    National Natural Science Foundation of China, 81171297, 81301200; Foundation of Science and Technology Commission of Shanghai Municipality, 11JC1412000

摘要:

目的 应用基于低频振幅(ALFF)的静息态功能磁共振成像(fMRI)技术,研究遗忘型轻度认知损害(aMCI)患者的静态脑活动特征及其可能的神经机制。方法 选取22例aMCI患者(aMCI组)作为研究对象,以22例轻度阿尔茨海默病患者(AD组)和25名健康老年人(正常组)作为对照。所有受试者接受fMRI检查,利用ALFF算法,对三组人群全脑静息态数据进行对比分析。结果 与正常组比较,aMCI组海马、海马旁回和侧颞叶皮质等脑区ALFF减弱,颞顶交界和顶下小叶ALFF增强;与AD组比较,aMCI组颞顶交界和后顶下小叶、前额叶背外侧等多个脑区ALFF增强;与正常组比较,AD组后扣带回、前额叶中内侧腹侧、前额叶中内侧背侧等脑区ALFF减弱。结论 aMCI患者与情景记忆密切相关的海马、海马旁回等脑区活动强度减低,颞顶交界和顶下小叶活动增强,提示aMCI患者脑内可能存在代偿机制。基于ALFF的静息态fMRI技术可为MCI的研究提供重要手段。

关键词: 轻度认知损害, 阿尔茨海默病, 静息态功能磁共振成像, 低频振幅

Abstract:

Objective To study the features of resting state brain activity of patients with amnestic mild cognitive impairment (aMCI) and its possible neural mechanisms by resting state functional magnetic resonance imaging (fMRI) technology based on the amplitude of lowfrequency fluctuation (ALFF). Methods Twenty-two patients with aMCI (aMCI group), 22 patients with mild Alzheimer's disease (AD group), and 25 healthy old people (normal group) were selected. All participants underwent the fMRI and the resting state data of whole brain of three groups was compared and analyzed by the ALFF method. Results Compared to the normal group, ALFF in the right hippocampus and parahippocampal cortex, left lateral temporal cortex, and right ventral medial prefrontal cortex (vMPFC) of patients of the aMCI group decreased, while ALFF in the left temporal-parietal junction (TPJ) and inferior parietal lobule (IPL) increased. Compared to the AD group, ALFF in the left TPJ, posterior IPL (pIPL), and dorsolateral prefrontal cortex of patients of the aMCI group increased. Compared to the normal group, ALFF in the right posterior cingulate cortex, right vMPFC, and bilateral dorsal MPFC (dMPFC) of patients of the AD group decreased. Conclusion For patients with aMCI, intrinsic activities of brain regions closely related to episodic memory (such as hippocampus and parahippocampal gyrus) decrease and activities of TPJ and IPL increase, which indicates that the compensatory mechanism may exist in the brain of patients with aMCI. The resting state fMRI technology based on ALFF may be an important tool for studying the aMCI.

Key words: mild cognitive impairment, Alzheimer's disease, resting-state functional magnetic resonance imaging, amplitude of low-frequency fluctuation