上海交通大学学报(医学版)

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白细胞介素6在学习记忆中的作用及机制

梁世桥1,苏 亮1,2,贾玉萍2,徐一峰1,2   

  1. 1.复旦大学附属华山医院精神科, 上海 200040; 2.上海交通大学医学院附属精神卫生中心, 上海 200030
  • 出版日期:2014-08-28 发布日期:2014-09-02
  • 通讯作者: 徐一峰, 电子信箱: hyyyyb@gmail.com。
  • 作者简介:梁世桥(1990—), 女, 硕士生; 电子信箱: lsq900519@126.com。
  • 基金资助:

    上海市市级医院新兴前沿技术联合攻关项目 (SHDC12010115)

Effects and mechanisms of interleukin-6 towards learning and memory

LIANG Shi-qiao1, SU Liang1,2, JIA Yu-ping2, XU Yi-feng1,2   

  1. 1.Department of Psychiatry, Huashan Hospital, Fudan University, Shanghai 200040, China; 2.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2014-08-28 Published:2014-09-02
  • Supported by:

    Emerging Frontier Technology Joint Research Program of City-Level Hospitals in Shanghai, SHDC12010115

摘要:

近年来研究表明,白细胞介素6 (IL-6)不仅作用于免疫系统,对学习记忆也有影响,但其具体作用及机制仍有争论。文章回顾了IL-6主要的信号通路及其影响学习记忆的研究,初步探讨IL-6对学习记忆的作用机制及相关影响因素。

关键词: 白细胞介素6, 学习, 记忆, 机制

Abstract:

Recent studies show that interleukin-6 (IL-6) influences not only the immune system, but also learning and memory, but the effects and mechanism are still controversial. This paper reviews studies on major signaling pathways and the effects of IL-6 on learning and memory and preliminarily discusses the mechanism and relevant influent factors of IL-6 towards learning and memory.

Key words: interleukin-6, learning, memory, mechanism