上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

慢性肾脏病5期非透析患者血清镁与冠状动脉粥样硬化性心脏病及左心室功能的相关性

张媛媛，王应灯   

  1. 上海交通大学医学院附属第九人民医院肾脏科， 上海 200011
  • 出版日期:2014-11-28 发布日期:2014-12-02
  • 通讯作者: 王应灯, 电子信箱: wangyd7001@sina.com。
  • 作者简介:张媛媛（1987—）， 女， 硕士生; 电子信箱: teresayyz@126.com。

Correlation of serum magnesium and coronary atherosclerotic heart disease and left ventricular function of stage 5 patients with non-dialysis chronic kidney disease

ZHANG Yuan-yuan, WANG Ying-deng   

  1. Department of Nephrology, the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Online:2014-11-28 Published:2014-12-02

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摘要：

目的 探讨慢性肾脏病（CKD）5期非透析患者血清镁浓度与冠状动脉粥样硬化性心脏病(CHD)及左心室功能的相关性。方法 43例CKD5期非透析患者根据是否患有CHD分为CHD组（24例）和对照组（19例），录入患者一般资料、血清镁、心率（HR）、每搏输出量（SV）、心搏指数（SI）、心输出量（CO）、心脏指数（CI）、射血前时间（PEP）、左心室射血时间（LVET）和PEP/LVET值。利用SPSS 15.0软件进行成组设计t检验及Pearson相关性分析。结果 与对照组相比，CHD组患者血清镁水平、SV、SI及LVET偏低(P＜0.05)。CHD组患者血清镁浓度与LVET呈正相关（r=0.66，P＜0.01），与PEP/LVET值呈负相关（r=－0.38，P＜0.05）。结论 CKD 5期非透析合并CHD患者的血清镁浓度偏低，且与左心室收缩功能相关。

关键词: 慢性肾脏病, 血清镁, 冠状动脉粥样硬化性心脏病, 左心室功能

Abstract:

Objective To investigate the correlation of serum magnesium level and coronary atherosclerotic heart disease (CHD) and left ventricular function of stage 5 patients with non-dialysis chronic kidney disease (CKD). Methods According to the history of CHD, 43 stage 5 patients with non-dialysis CKD were divided into the CHD group (n=24) and control group (n=19). Basic information, serum magnesium, heart rate (HR), stroke volume (SV), stroke index (SI), cardiac output (CO), cardiac index (CI), pre-ejection period (PEP), left ventricular ejection time (LVET), and PEP/LVET of patients were recorded. The t test and Pearson correlation analysis were conducted by the SPSS 15.0. Results The serum magnesium level, SV, SI, and LVET of the CHD group were lower than those of the control group (P<0.05). The serum magnesium level of the CHD group positively correlated to LVET (r=0.66, P<0.01) and negatively correlated to PEP/LVET (r=－0.38, P<0.05). Conclusion The serum magnesium level of stage 5 patients with non-dialysis CKD and CHD was low and relevant to the left ventricular systolic function.

Key words: chronic kidney disease, serum magnesium, coronary atherosclerotic heart disease, left ventricular function