上海交通大学学报（医学版）

上海交通大学学报（医学版）

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SFRP3与肿瘤关系的研究进展

林亚英，张 萍   

  1. 上海交通大学医学院附属新华医院妇科， 上海 200092
  • 出版日期:2015-02-28 发布日期:2015-02-27
  • 通讯作者: 张 萍, 电子信箱: zjqzp@126.com。
  • 作者简介:林亚英(1990—)， 男， 硕士生; 电子信箱: linyaying19900922@126.com。

Advances of relationship between SFRP3 and tumors

LIN Ya-ying, ZHANG Ping   

  1. Department of Gynecology,Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2015-02-28 Published:2015-02-27

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摘要：

Wnt信号通路在胚胎发育、组织内稳态及肿瘤发生和发展等生物学行为中发挥重要作用，许多因素影响Wnt信号的表达。分泌型卷曲相关蛋白（SFRPs）家族是重要的Wnt拮抗因子，它们在胞外与Wnt或其受体Fz结合抑制Wnt信号的传递。分泌型卷曲相关蛋白3(SFRP3)作为最早发现的SFRPs成员，其启动子甲基化导致的沉默与恶性肿瘤的发生和发展密切相关，故SFRP3通常被认为是一种抑癌基因，SFRP3的基因多态性也被发现是部分恶性肿瘤的高危因素。该文就SFRP3与肿瘤关系的研究进展进行综述。

关键词: 分泌型卷曲相关蛋白3, Wnt信号通路, 甲基化, 多态性, 肿瘤

Abstract:

The Wnt signaling pathway plays an important role in biological behaviors, such as embryonic development, tissue homeostasis, and tumor progression. The expression of Wnt signal was affected by many factors. The secreted frizzled-related protein (SFRPs) family is an important inhibitor of Wnt which extracellularly binds to Wnt or frizzled (Fz) receptor of Wnt to inhibit the transmission of Wnt signal. Secreted frizzled-related protein-3 (SFRP3) is the first discovered member of SFRPs. The silence of SFRP3 caused by the methylation of its promoter is closely relevant to the incidence and development of malignant tumors, so SFRP3 is often regarded as a tumor suppressor gene. The gene polymorphism of SFRP3 is also a high risk factor of some malignant tumors. This paper reviews research progresses of the relationship between SFRP3 and tumors.

Key words: secreted frizzled-related protein-3, Wnt pathway, methylation, polymorphism, tumor