上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 综述 • 上一篇    下一篇

趋化因子CCL19在介导免疫细胞抗肿瘤中的作用

关少培，陆爱国   

  1. 上海交通大学 医学院附属瑞金医院上海市微创外科临床医学中心， 上海 200025
  • 出版日期:2015-03-28 发布日期:2015-03-26
  • 通讯作者: 陆爱国, 电子信箱: adams_lu66@aliyun.com。
  • 作者简介:关少培（1989—）， 男， 硕士生; 电子信箱: nt491137284@126.com。

Role of chemokine CCL19 in immune cell mediated antitumor effect

GUAN Shao-pei, LU Ai-guo   

  1. Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2015-03-28 Published:2015-03-26

PDF (PC)

1750

摘要：

趋化因子是一类能趋化免疫细胞定向移动的小分子分泌蛋白。趋化因子CCL19和其受体CCR7在树突状细胞、T细胞和多种肿瘤细胞上表达。近年来，CCL19及CCR7在抗肿瘤治疗中的作用成为研究热点并取得显著进展，它们在趋化树突状细胞、CD4+和CD8+ T细胞浸润肿瘤,介导免疫细胞释放细胞因子,抑制肿瘤增殖、迁移和侵袭以及协助治疗肿瘤过程中发挥关键作用，对其深入研究有助于找到新的肿瘤治疗手段和基因疫苗。该文对CCL19在介导免疫细胞抗肿瘤中的作用作一综述。

关键词: 趋化因CCL19, 受体CCR7, 树突状细胞, 肿瘤

Abstract:

Chemokines are a family of small cytokines secreted by immune cells, which act as a chemoattractant to guide the migration of immune cells. It has been reported that CCL19 (chemokine C-C motif ligand 19) and its receptor CCR7 (a seven transmembrane protein) are expressed in dendritic cells, CD4+ and CD8+T cells and variety of tumor cells. Recently, more attention has been focused on the antitumor effect of CCL19 and its receptor CCR7, which has been well-documented in the literature and was vital to attracting dendritic cells, infiltration of tumors by CD4+ and CD8+T cells, mediating immune cells to release cytokines, inhibiting the proliferation, invasion, and migration of tumors, and assisting the treatment of tumors. Further studies on CCL19 and CCR7 are helpful for developing new treatments of tumors and gene vaccines. This paper reviews the role of CCL19 the immune cell mediated antitumor therapy.

Key words: chemokine CCL19, receptor CCR7, dendritic cells, tumor