上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

微乳头型单纯黏液癌伴浸润性微乳头状癌的临床病理观察

徐明1，叶曼娜1，汪成2，叶辉3   

  1. 上海市黄浦区中心医院 1.病理科， 2.乳腺外科， 3.外科， 上海 200002
  • 出版日期:2015-04-28 发布日期:2015-04-29
  • 通讯作者: 叶辉, 电子信箱: yehui1969@126.com。
  • 作者简介:徐明（1969—）， 男， 副主任医师， 学士; 电子信箱: xujshan@sina.com。
  • 基金资助:

    上海市医学重点专科建设项目（ZK2012A13）

Clinicopathological observation of breast micropapillary pure mucinous carcinoma combined with invasive micropapillary carcinoma

XU Ming1, YE Man-na1, WANG Cheng2, YE Hui3   

  1. 1.Department of Pathology, 2.Department of Breast Surgery,  3.Department of Surgery, Central Hospital of Huangpu District, Shanghai 200002, China
  • Online:2015-04-28 Published:2015-04-29
  • Supported by:

    Construction Project of Shanghai Medical Key Discipline, ZK2012A13

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摘要：

目的 探讨微乳头型单纯黏液癌（MPPMC）与MPPMC伴有乳腺浸润性微乳头状癌（IMPC）病例的临床病理特点。方法 收集8例MPPMC和5例MPPMC伴IMPC病例的临床病理资料，对组织形态、免疫表型及临床特点进行分析。结果 5例MPPMC伴IMPC均见2种形态之间的移行过渡，微乳头周围黏液逐渐消失，形成IMPC。在MPPMC向IMPC转化后癌组织Ki-67的表达率显著增高。MPPMC组淋巴结转移率仅为12.5%，而MPPMC伴IMPC组淋巴结转移率高达80%。淋巴结转移灶中以IMPC形态为主。结论 乳腺MPPMC与IMPC可能处于同一肿瘤谱系。MPPMC伴IMPC生物学行为更差，治疗原则要参照IMPC。

关键词: 乳腺癌, 微乳头状, 免疫组织化学, 预后

Abstract:

Objective To explore the clinicopathological features of micropapillary pure mucinous carcinoma (MPPMC) and MPPMC combined with invasive micropapillary carcinoma (IMPC). Methods Clinical pathological data of 8 cases of MPPMC and 5 cases of MPPMC combined with IMPC were collected and the histological morphology, immune phenotypes, and clinical features were analyzed. Results Transitional regions were observed in 5 cases of MPPMC combined with IMPC. The mucus around the micropapillary gradually disappeared and formed IMPC. The expression of Ki-67 in cancer tissues significantly increased after the transformation of MPPMC to IMPC. The rate of lymph node metastasis of the MPPMC group was only 12.5%, while that of the MPPMC combined with IMPC group was 80%. The main type of cancer in lymph node metastases was IMPC. Conclusion Breast MPPMC and IMPC may be in the same tumor lineages. The biological behavior of MPPMC combined with IMPC is more serious. The treatment of MPPMC combined with IMPC should reference that of IMPC.

Key words: breast carcinoma, micropapillary, immunohistochemistry, prognosis