上海交通大学学报(医学版)

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NLRP3炎症小体在脑缺血再灌注损伤中的作用

高丽1,2,沈沸1,2,李焰生1,2   

  1. 上海交通大学 医学院 1.附属仁济医院南院神经内科, 上海 201112; 2.附属仁济医院神经内科, 上海 200127
  • 出版日期:2015-12-28 发布日期:2016-01-21
  • 通讯作者: 李焰生, 电子信箱: lliyans@hotmail.com。
  • 作者简介:高丽(1986—), 女, 住院医师, 博士; 电子信箱: gaoli246619@126.com。
  • 基金资助:

    上海交通大学医学院附属仁济医院科研种子基金培养计划(RJZZ-14-018)

Effects of NLRP3 inflammasome  on cerebral ischemia-reperfusion injury

GAO Li1,2, SHEN Fei1,2, LI Yan-sheng1,2   

  1. 1.Department of Neurology, Renji Hospital South Campus, Shanghai Jiao Tong University School of Medicine, Shanghai 201112, China; 2.Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2015-12-28 Published:2016-01-21
  • Supported by:

    Research seed training program of Renji Hospital, Shanghai Jiao Tong University, RJZZ-14-018

摘要:

缺血再灌注损伤是一个涉及多种因素相互作用的炎症级联反应过程。近年来,众多研究表明,NLRP3炎症小体作为先天免疫重要的模式识别受体参与了缺血再灌注的炎症损伤,阻断或抑制NLRP3的活化可能成为缺血性脑血管病新的治疗靶点。然而,NLRP3在脑缺血发生发展过程中的作用机制还不清楚,该文就NLRP3炎症小体在脑缺血再灌注损伤中的作用与意义作一综述。

关键词: 脑缺血, NLRP3炎症小体, 缺血再灌注损伤

Abstract:

Ischemia-reperfusion injury is an inflammatory cascade process involving the interaction of multiple factors. In recent years, numerous studies have shown that as an important pattern recognition receptor of innate immune,  NLRP3 inflammasome involves in the inflammatory injury of cerebral ischemia-reperfusion. Thus blockage or inhibition of the activation of NLRP3 may be a new therapeutic target for the treatment of ischemic cerebrovascular diseases. However, the mechanisms of NLRP3 during the occurrence and development of cerebral ischemia are still unclear. This paper reviews the role and significance of NLRP3 inflammasome in cerebral ischemia-reperfusion injury.

Key words: cerebral ischemia, NLRP3 inflammasome, ischemia-reperfusion injury