上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

ANK3基因在精神分裂症认知功能障碍发生中的作用研究

吕望强1， 唐伟2， 蔡军3， 卢卫红3， 喻跃国1， 范卫星1， 张晨1,3   

  1. 1.浙江省金华市第二医院， 金华 321016； 2.浙江省温州市康宁医院， 温州 325000； 3.上海交通大学 医学院附属精神卫生中心， 上海 200030
  • 出版日期:2016-09-28 发布日期:2016-10-31
  • 通讯作者: 张晨， 电子信箱： zhangchen645@gmail.com。
  • 作者简介:吕望强（1966—）， 男， 副主任医师， 学士； 电子信箱： lvwangqiang@126.com。
  • 基金资助:

    国家自然科学基金（81471358）；金华市科学技术局项目（2015-3-063）；上海市科学技术委员会西医引导类项目（14411969000）；上海市教育委员会高峰高原学科建设计划（20152530）；上海市卫生与计划生育委员会科研项目（201540029）

Study on the effects of ANK3 gene on the development of cognitive impairment in patients with schizophrenia

LÜ  Wang-qiang1, TANG Wei2, CAI Jun3, LU Wei-hong3, YU Yue-guo1, FAN Wei-xing1, ZHANG Chen1,3   

  1. 1.Jinhua Second Hospital, Jinhua 321016, China; 2.Wenzhou Kangning Hospital, Wenzhou 325000, China; 3.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2016-09-28 Published:2016-10-31
  • Supported by:

    National Natural Science Foundation of China, 81471358; Jinhua Science and Technology Bureau Foundation, 2015-3-063; Shanghai Municipal Science and Technology Commission Foundation, 14411969000; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152530; Shanghai Municipal Commission of Health and Family Planning Foundation, 201540029

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摘要：

目的·探讨ANK3基因对精神分裂症患者认知功能的影响。方法·收集稳定期精神分裂症患者254例，健康对照者72名，采用重复性神经心理状态测验（RBANS）测试研究对象认知功能，使用TaqMan试验方法对ANK3基因rs10994336位点多态性进行基因分型。结果·病例组与对照组间性别比较差异无统计学意义（P=0.18），年龄及受教育年限比较差异有统计学意义（P<0.01）；RBANS测试中，患者组的即刻记忆、视觉广度、言语功能、注意力、延时记忆及总分评分显著低于对照组（P<0.01）；携带rs10994336位点3种不同基因型患者的RBANS测试中即刻记忆、注意力、延时记忆和总分比较差异有统计学意义（P<0.01），其中携带T/T基因型者RBANS评分显著低于携带C/C基因型者。结论·ANK3基因与精神分裂症患者认知功能障碍存在显著关联，尤其是即刻记忆、注意和延时记忆方面，提示ANK3基因可能参与了精神分裂症认知功能障碍的形成过程。

关键词: ANK3基因, 认知功能, 精神分裂症, 基因多态性, 关联分析

Abstract:

Objective·To investigate the effects of ANK3 gene on the cognitive function in patients with schizophrenia. Methods·A total of 254 schizophrenia patients with stable condition and 72 healthy controls were recruited. Cognitive function was tested using RBANS and SNP rs10994336 was genotyped using TaqMan SNP genotyping assay. Results·The difference in sex between case group and control group was not statistically significant (P=0.18), while the differences in age and education were statistically significant (P<0.01). In the RBANS evaluation, patients in case group had much higher total scores and scores in immediate memory, visual span, language ability, attention, and delayed memory compared with the control group (P<0.01). The differences in the total score and scores of immediate memory, attention, and delayed memory between patients carrying three different genotypes of rs10994336 were statistically significant (P<0.01). Patients carrying T/T genotype had significantly lower RBANS scores than those carrying C/C genotype. Conclusion·ANK3 gene is significantly associated with cognitive impairment in patients with schizophrenia, especially in terms of immediate memory, attention, and delayed memory, suggesting ANK3 gene may participate in the development of cognitive impairment in patients with schizophrenia.

Key words: ANK3 gene, cognitive function, schizophrenia, genetic polymorphism, correlation analysis