上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (6): 769-.doi: 10.3969/j.issn.1674-8115.2017.06.010

• 论著（临床研究） • 上一篇    下一篇

血清 S100B 蛋白与双相障碍抑郁发作及其预后的相关性研究

张载福 1，杨帆 1，王卫平 1，施波 1，赵俊雄 1，吕望强 1，喻跃国 1，贾玉萍 2，张晨 1, 2   

  1. 1. 浙江省金华市第二医院，金华 321016；2. 上海交通大学 医学院附属精神卫生中心，上海 200030
  • 出版日期:2017-06-28 发布日期:2017-07-05
  • 通讯作者: ?张晨，电子信箱：zhangchen645@gmail.com
  • 作者简介:张载福（1960—），男，主任医师，学士；电子信箱：zaifu500@sina.com
  • 基金资助:

     国家自然科学基金（81471358）；金华市科学技术局重点项目（2015-3-022）；上海市科学技术委员会项目（14411969000）；上海市教育委员会高 峰高原学科建设计划（20152530）；上海市卫生与计划生育委员会科研项目（201540029）

Correlation of serum S100B protein with depressive episode of bipolar disorder and its prognosis

ZHANG Zai-fu1, YANG Fan1, WANG Wei-ping1, SHI Bo1, ZHAO Jun-xiong1, LÜ Wang-qiang1, YU Yue-guo1, JIA Yu-ping2, ZHANG Chen1, 2   

  1. 1. Jinhua Second Hospital, Jinhua 321016, China; 2. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2017-06-28 Published:2017-07-05
  • Supported by:

    National Natural Science Foundation of China, 81471358; Key Project of Jinhua Science and Technology Beaureu, 2015-3-022; Project of Shanghai Municipal Science and Technology Commission, 14411969000; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152530; Foundation of Shanghai Municipal Commission of Health and Family Planning, 201540029

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摘要：

目的 · 探讨血清 S100B 蛋白水平与双相障碍抑郁发作及其预后的相关性。方法 · 根据美国精神病协会《精神障碍诊断与统计 手册》第 4 版（DSM- Ⅳ）诊断标准，入组双相障碍抑郁发作患者 80 例（病例组）以及健康对照者 42 名（对照组）。病例组患者采用 随机数字表法进入碳酸锂联合喹硫平治疗组（喹硫平组）及碳酸锂合并改良无抽搐电休克治疗组（MECT 组）；治疗前及治疗 4 周末 分别测定 2 组血清 S100B 水平并评定汉密尔顿抑郁量表（HAMD）。 结果 · 经过 4 周随访，喹硫平组共完成36 例，MECT 组完成 31 例。病例组治疗前血清 S100B 水平显著高于对照组（P=0.000）；治疗后，喹硫平组与 MECT 组患者血清 S100B 水平均较治疗前显著 下降，HAMD 评分均较治疗前显著降低（P=0.000）； Pearson 相关分析显示病例组治疗前后血清 S100B 变化水平与 HAMD 评分变化值 呈正相关（r=0.33，P=0.013）。 结论 · S100B 可能与双相障碍抑郁发作以及预后有关。

关键词: &ensp, 双相障碍, 抑郁发作, S100B, 无抽搐电休克治疗

Abstract:

Objective · To explore the correlation of serum S100B protein with depressive episode of bipolar disorder (BD) and its prognosis.  Methods · Based on BD criteria of Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM- Ⅳ ), 80 patients with depressive episode of BD (case group) and 42 healthy controls (control group) were enrolled. Patients were randomly assigned into quetiapine group who were treated with lithium and quetiapine and modified electroconvulsive therapy (MECT) group who received lithium and MECT. The serum S100B level and Hamilton Rating Scale for Depression (HAMD) were assayed before and after 4-week treatment.  Results · The serum S100B levels before treatment in patients with depressive episode of BD were significantly higher than those in healthy controls (P=0.000). The levels of S100B in both drug and MECT groups decreased after 4-week treatment. The HAMD score after treatment significantly decreased than that before treatment (P=0.000). Pearson correlation analysis showed that the change of S100B level was positively correlated with the change of HAMD score before and after treatment in case group (r=0.33, P=0.013).  Conclusion · S100B may be associated with depressive episode of BD and its prognosis.

Key words:  bipolar disorder, depressive episode, S100B, modified electroconvulsive therapy