上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (4): 445-.doi: 10.3969/j.issn.1674-8115.2018.04.017

• 综述 • 上一篇    下一篇

精原干细胞自我更新与分化机制的研究进展

林南河，朱子珏，李铮   

  1. 上海交通大学附属第一人民医院泌尿外科中心男科/盆底尿失禁外科，上海 200080
  • 出版日期:2018-04-28 发布日期:2018-05-03
  • 通讯作者: 李铮，电子信箱：lizhengboshi@163.com。
  • 作者简介:林南河（1994—），男，博士生；电子信箱：lin.nh@foxmail.com。
  • 基金资助:
    国家自然科学基金面上项目（81671512）；国家重点研发计划（2017YFC1002003）；上海市级医院新兴前沿技术联合攻关项目（SHDC12014236）

Research progress in mechanisms of self-renewal and differentiation of spermatogonial stem cells

LIN Nan-he, ZHU Zi-jue, LI Zheng   

  1. Department of Andrology/Pelvic Floor Dysfunction, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080
  • Online:2018-04-28 Published:2018-05-03
  • Supported by:
    National Natural Science Foundation of China, 81671512; National Key Research and Development Program of China, 2017YFC1002003; Frontier Technology Project of Shanghai Hospital Development Center, SHDC12014236

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摘要： 正常精子发生起始于精原干细胞（spermatogonial stem cell，SSC）。SSC是具有自我更新与分化潜能的生殖干细胞，在多种生长因子、微环境和自身信号调控下最终分化为精子。SSC自我更新相关的分子包括胶质细胞来源神经生长因子、成纤维细胞生长因子及其下游信号通路、转录因子和表观调控因子等；SSC分化相关的分子包括视黄酸、多种转录因子及表观调控因子等。SSC自我更新与分化的机制研究，对于深入理解精子发生及男性精子发生障碍性不育的诊治有重要意义。该文就近几年SSC自我更新与分化调控相关的外源性因子、转录因子及表观调控因子等进行综述。

关键词: 精原干细胞, 自我更新, 分化

Abstract:

Spermatogenesis originates spermatogonial stem cells (SSCs). SSCs can continually renew and eventually differentiate into spermatozoa under control of various growth factors, microenvironments and self-signaling. The molecules involved in SSCs self-renewal include glial cell-derived nerve growth factor, fibroblast growth factor and downstream signaling pathways, as well as the transcription factors and the epigenetic regulators. Molecules related to SSCs differentiation include retinoic acid, a variety of transcription factors and the eptigenetic regulatory factors. The research on the mechanism of SSCs self-renewal and differentiation is of great significance for the understanding of spermatogenesis and the diagnosis and treatment of male infertility. This review summarized the exogenous factors, transcription factors, and epigenetic regulators that are involved in the regulation of SSCs self-renewal and differentiation in recent years.

Key words: spermatogonial stem cell, self-renewal, differentiation

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