上海交通大学学报(医学版) ›› 2018, Vol. 38 ›› Issue (7): 801-.doi: 10.3969/j.issn.1674-8115.2018.07.016

• 综述 • 上一篇    下一篇

5-羟色胺2C受体作为精神分裂症治疗靶点的研究进展

汪也微,张晨   

  1. 上海交通大学医学院附属精神卫生中心生化研究室,上海 200030
  • 出版日期:2018-07-28 发布日期:2018-07-30
  • 通讯作者: 张晨,电子信箱:zhangchen645@gmail.com。
  • 作者简介:汪也微(1993—),女,硕士生;电子信箱:yuhanwang801@163.com。
  • 基金资助:
    国家自然科学基金(81000581,81471358,81771450);国家临床重点专科—上海市精神卫生中心(卫计委医政司2011-873);上海市科学技术发展基金(12140904200);上海市教育委员会高峰高原学科建设计划(20152530)

Progress in 5-HT2C receptor as a therapeutic target for treatment of schizophrenia

WANG Ye-wei, ZHANG Chen   

  1. Biochemical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2018-07-28 Published:2018-07-30
  • Supported by:
    National Natural Science Foundation of China, 81000581, 81471358, 81771450; National Key Clinical Discipline at Shanghai Mental Health Center, OMA-MH 2011-873; Shanghai Science and Technology Development Fund, 12140904200; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20152530)。

摘要: 随着第2代抗精神病药物引起体质量增加和心血管不良反应的报道越来越多,研究者近年来开始将关注点投向治疗精神分裂的新靶点——5-羟色胺2C受体(5-HT2C受体)。一方面,有研究表明激动5-HT2C受体具有降低黑质纹状体多巴胺的作用,推测其潜在的抗精神病作用;另一方面,第2代抗精神病药物对5-HT2C受体的拮抗作用是其引起患者体质量增加的重要因素,反之激动5-HT2C受体则可能具有降低体质量的效应。该文以文献综述的形式就5-HT2C受体的抗精神病效应和与之相关的体质量增加不良反应进行阐述。

关键词: 5-羟色胺2C受体, 精神分裂症, 抗精神病药所致的体质量增加, 基因多态性, 戊卡色林

Abstract:

With an increasing number of reports on side effects including antipsychotic induced weight gain and cardiovascular risks, interest of the researchers has been transferred to a new target for the treatment of schizophrenia—serotonin 2C receptor (5-HT2C receptor). On one hand, activation on 5-HT2C receptors can lead to decrease of dopamine in the nigrostriatum, which presents its potential antipsychotic effect; on the other hand, the second-generation of antipsychotics’ antagonism on the 5-HT2C receptors is an important factor of patients weight gain. Conversely, agonism on the 5-HT2C receptors may result in weight loss efficacy. This paper introduced the potential therapeutical effect of 5-HT2C receptor on schizophrenia and the relation between the receptor and correlated weight gain.

Key words: serotonin 2Creceptor (5-HT2Creceptor), schizophrenia, antipsychotic induced weight gain, gene polymorphism, vabicaserin

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