上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (12): 1457-.doi: 10.3969/j.issn.1674-8115.2018.12.011

• 论著·临床研究 • 上一篇    下一篇

乳腺癌化学治疗患者更年期症状相关生活质量及影响因素研究

袁晓玲 1，尤婧蓉 1，沈莉莉 2，李素云 3，沈丹薇 4，蔡灵芝 5，陈颖丹 1，朱涵菁 1，袁长蓉 6   

  1. 1. 上海交通大学护理学院综合教研室，上海 200025；2. 上海交通大学医学院附属瑞金医院乳腺疾病诊治中心，上海 200025；3. 华中科技大学同济医学院附属协和医院外科，武汉 430022；4. 河北省唐山市人民医院护理部，唐山 063001；5. 浙江省杭州市第一人民医院乳腺诊治中心，杭州 310006；6.复旦大学护理学院，上海 200032
  • 出版日期:2018-12-28 发布日期:2019-01-27
  • 通讯作者: 袁长蓉，电子信箱：yuancr510@aliyun.com。
  • 作者简介:袁晓玲（1983—），女，讲师，硕士生；电子信箱： xiaolingy@shsmu.edu.cn。
  • 基金资助:
    上海市教育委员会护理高原学科建设项目（ hlgy16035kygg）；上海卫生和计划生育委员会科研课题（ 20164Y0135）

Study on the predictors of the menopausal symptoms related quality of life in patients with breast cancer undergoing chemotherapy

YUAN Xiao-ling1, YOU Jing-rong1, SHEN Li-li2, LI Su-yun3, SHEN Dan-wei4, CAI Ling-zhi5, CHEN Ying-dan1, ZHU Han-jing1, YUAN Chang-rong6   

  1. 1. Shanghai Jiao Tong University School of Nursing, Shanghai 200025, China; 2. Comprehensive Breast Health Centre, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 3. Department of Surgery, Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; 4. Department of Nursing, Tangshan People’s Hospital, Hebei Province, Tangshan 063001, China; 5. Comprehensive Breast Health Centre, Hangzhou First Peoples Hospital, Zhejiang Province, Hangzhou 310006, China; 6. Fudan University School of Nursing, Shanghai 200032, China
  • Online:2018-12-28 Published:2019-01-27
  • Supported by:
    Shanghai Municipal Education Commission Gao-yuan Nursing Support, hlgy16035kygg; Scientific Research Foundation of Shanghai Municipal Commission of Health and Family Planning, 20164Y0135

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摘要： 目的 ·调查乳腺癌化学治疗（化疗）患者更年期症状相关生活质量，探讨其影响因素，为构建相应的干预措施提供理论依据。方法 · 2016年 7月— 2017年 12月，采用方便抽样法，选取全国 9所医院 484名正在接受化疗的乳腺癌患者为调查对象进行问卷调查。对可能影响患者生活质量的因素进行单因素分析及 Spearman相关分析，对有统计学意义的因素进行多元线性回归分析。结果 ·乳腺癌化疗患者更年期症状相关生活质量总分为（9.580±6.174）分，75.8%患者总分大于 4分，提示生活质量较差。单因素分析发现，月经状态改变、婚姻状况及家庭月收入水平对患者的更年期症状相关生活质量的影响有统计学意义；相关性分析发现，化疗症状、焦虑抑郁与生活质量呈正相关，社会支持水平与生活质量呈负相关。进一步经多元逐步回归法分析，化疗症状、焦虑情绪、讯息与情绪支持 3个变量进入回归方程，可共同解释总变异的 43.0%（P<0.01）。结论 ·化疗症状及焦虑情绪的协同作用会影响乳腺癌化疗患者的更年期症状相关生活质量，应积极提供讯息与情绪支持，加强心理干预等多维度措施，改善患者生活质量。

关键词: 乳腺癌, 化学治疗, 更年期症状, 生活质量, 影响因素分析

Abstract:

Objective · To survey the menopausal symptoms related quality of life in patients with breast cancer undergoing chemotherapy and its determinants, which provides theoretical basis on intervention. Methods · In this cross-sectional study, a questionnaire survey was conducted on 484 breast cancer patients undergoing chemotherapy in 9 hospitals nationwide recruitedconvenience sampling approach, July 2016 to December 2017. Descriptive statistics, ANOVA, Spearman correlation and multiple linear regression analyses were preformed to explore the risk factors of the menopausal symptoms related quality of life. Results · The mean score of the MenopaRating Scale (MRS) was 9.580±6.174 with 75.8% larger than 4, which indicated poor quality of life. One-Way ANOVA results showed the effect of marital status, monthly income, and the change of menstrual status on the MRS score were statistically significant. Spearman correlation results showed that the MRS score was positive correlated with anxiety and depression score and chemotherapy symptoms score, but negative correlated with social support score. Three of the nine variables, chemotherapy symptoms, anxiety, and information and emotional support, were selectedthe multiple linear stepwise regression analysis, and could explain 43.0% of total variance (P<0.01). Conclusion · Most breast cancer patients undergoing chemotherapy have poor menopausal symptoms related quality of life. The main determinants were chemotherapy symptoms, anxiety, and information and emotional support. Informational and emotional support should be actively provided and mental health interventions should be strengthened, which could effectively improve their quality of life.

Key words: breast cancer, chemotherapy, menopausal symptoms, quality of life, root caanalysis

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