上海交通大学学报(医学版) ›› 2019, Vol. 39 ›› Issue (6): 671-.doi: 10.3969/j.issn.1674-8115.2019.06.018

• 综述 • 上一篇    下一篇

肠道法尼醇 X受体对糖脂代谢调节作用的研究进展

赵明亮 1, 2,赵爱华 1,郑晓皎 1,贾伟 1   

  1. 1. 上海交通大学附属第六人民医院转化医学中心,上海 200233;2. 上海交通大学生物医学工程学院,上海 200030
  • 出版日期:2019-06-28 发布日期:2019-07-26
  • 通讯作者: 贾伟,电子信箱:weijia@sjtu.edu.cn。
  • 作者简介:赵明亮(1993—),男,博士生;电子信箱: zmlecho@126.com。
  • 基金资助:
    国家自然基金面上项目(81772530)

Role of farnesol X receptor in glycolipid metabolism regulation

ZHAO Ming-liang1, 2, ZHAO Ai-hua1, ZHENG Xiao-jiao1, JIA Wei1   

  1. 1. Center for Translational Medicine, Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai 200233, China; 2. Shanghai Jiao Tong University School of Biomedical Engineering, Shanghai 200030, China
  • Online:2019-06-28 Published:2019-07-26
  • Supported by:
    National Natural Science Foundation of China, 81772530)。

摘要: 法尼醇 X受体(farnesol X receptor,FXR),又称为胆汁酸核受体,是配体依赖性的核转录因子,可分布于体内肝脏、肠道等多个组织器官;胆汁酸是其内源性天然配体。近年有研究表明,肠道 FXR对于糖脂代谢调节具有不可或缺的作用,肠道特异性 FXR激动剂或抑制剂均可参与体内糖脂代谢调节。该文对近年来报道的肠道 FXR在糖脂代谢中的作用进行系统的综述。

关键词: 法尼醇 X受体, 胆汁酸, 糖脂代谢, 激动剂, 抑制剂

Abstract:

Farnesol X receptor (FXR), also known as bile acid nuclear receptor, is a ligand-dependent nuclear transcription factor distributed in multiple tissues and organs such as liver and intestinal tract. And bile acid is its endogenous natural ligand. Recent studies have shown that intestinal FXR plays an indispensable role in glycolipid metabolism regulation, and intestinal specific FXR agonists or antagonists can participate in glucose and lipid metabolism regulation in vivo. In this paper, the role of intestinal FXR in glycolipid metabolism reported in recent years is systematically reviewed.

Key words: farnesol X receptor (FXR), bile acid, glycolipid metabolism, agonist, antagonist

中图分类号: