上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (1): 134-.doi: 10.3969/j.issn.1674-8115.2020.01.022

• 综述 • 上一篇    下一篇

干细胞来源的细胞外囊泡修复治疗中枢神经系统疾病的研究进展

何征晖1,汪 泱2,邓志锋3   

  1. 1. 上海交通大学附属第六人民医院临床医学院,上海 200233;2. 上海交通大学附属第六人民医院四肢显微外科研究所,上海 200233;3.上海交通大学附属第六人民医院神经外科,上海 200233
  • 出版日期:2020-01-28 发布日期:2020-03-05
  • 通讯作者: 邓志锋,电子信箱:dengzf63@126.com。
  • 作者简介:何征晖(1995—),男,本科生;电子信箱:hezhenghui8@qq.com。
  • 基金资助:
    国家自然科学基金(81671209)。

Recent advances in using of stem cell-derived extracellular vesicles in treating central nervous system diseases

HE Zheng-hui, WANG Yang, DENG Zhi-feng   

  1. 1. School of Clinical Medicine, Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai 200233, China; 2.Institute of Microsurgery on Extremities, Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai 200233, China; 3. Department of Neurosurgery, Shanghai Sixth Peoples Hospital Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2020-01-28 Published:2020-03-05
  • Supported by:
    National Natural Science Foundation of China (81671209).

摘要: 干细胞来源的细胞外囊泡(stem cell-derived extracellular vesicles,SC-EVs)能够调节病变细胞功能及微环境,且不具有干细胞移植的风险,能更安全地用于疾病治疗。在中枢神经系统损伤病灶中,SC-EVs能够促进神经血管再生并抑制炎症损伤,有利于神经功能康复。SC-EVs可减少Aβ蛋白相关的神经损伤,缓解阿尔茨海默病。SC-EVs还可以作为微RNA及化疗药物的运输载体治疗神经胶质瘤。该文就SC-EVs在中枢神经系统疾病治疗中应用的研究成果进行综述。

关键词: 干细胞来源的细胞外囊泡, 中枢神经系统损伤, 阿尔茨海默病, 神经胶质瘤

Abstract:

Stem cell-derived extracellular vesicles can regulate functions of targeting cells in lesions and have fewer risks in treating diseases. In central nervous injury lesions, stem cell-derived extracellular vesicles can promote neurogenesis and angiogenesis and regulate nervous inflammation, which promotes the recovery of the nerve injury. Stem cell-derived extracellular vesicles can ease Aβ protein-related neuron damage in Alzheimers disease. Stem cell-derived extracellular vesicles also can deliver microRNA and chemotherapeutic agents to neuroglioma cells. This review introduces recent advances in using stem cell-derived extracellular vesicles in treating central nervous system diseases.

Key words: stem cell-derived extracellular vesicles (SC-EVs), central nervous system injury, Alzheimer’s disease, neuroglioma