上海交通大学学报(医学版)

上海交通大学学报（医学版）

• 新型冠状病毒防控专栏 • 上一篇    下一篇

新型冠状病毒（SARS-CoV-2）传播的溯源分析及启示

王晓钰，崔 立   

  1. 上海交通大学农业与生物学院，上海市兽医生物技术重点实验室，上海 200240
  • 出版日期:2020-02-27 发布日期:2020-02-27
  • 通讯作者: 崔 立，电子信箱：lcui@sjtu.edu.cn。
  • 作者简介:王晓钰（1996—），女，硕士生；电子信箱：haileyxywang@sjtu.edu.cn。
  • 基金资助:
    国家重点研发计划（2017YFC1200202）；上海交通大学科技创新专项资金（2020-RK11）。

A source-seeking analysis and its implication on the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

WANG Xiao-yu, CUI Li   

  1. Shanghai Key Laboratory of Veterinary Biotechnology, Shanghai Jiao Tong University School of Agriculture and Biology, Shanghai 200240, China
  • Online:2020-02-27 Published:2020-02-27
  • Contact: CUI Li, E-mail: lcui@sjtu.edu.cn.
  • Supported by:
    National Key R&D Program of China (2017YFC1200202); Shanghai Jiao Tong University Scientific and Technological Innovation Funds (2020-RK11).

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摘要： 由新型冠状病毒 SARS-CoV-2（severe acute respiratory syndrome coronavirus 2）感染引起的疫情严重危害人类的生命安全，给社会造成巨大经济损失。目前，SARS-CoV-2 从源头到感染人类过程中，哪些动物充当了传播媒介的角色尚未有定论。找到 SARS-CoV-2 的动物宿主来源并切断传播途径是防控传染病的有效措施，对预防疫情再次发生、保障社会公共卫生安全具有重要意义。该文总结了 SARS-CoV-2 传播宿主的最新研究进展，并依据疫情事实推测 SARS-CoV-2 从蝙蝠到人类可能存在多个中间宿主。因此，在当前疫情防控乃至未来对新发传染病的防控中，基于同一健康创新理念加强人类医学 - 动物医学一体化防控体系建设至关重要。
【该文已在2020年02期正式发表】

关键词: 新型冠状病毒, 蝙蝠, 中间宿主, 同一健康

Abstract: The epidemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has seriously compromised the security of human life as well as resulted in huge economic damages. Currently, it has yet to be determined that who are the intermediate animals of SARS-CoV-2 transmission during the transition from its origin to the human infection. In order to prevent and control infectious diseases, the effective measures are identifying the animals serving as the source and intermediate hosts and interrupting the transmission pathways. They are thus highly significant in the prevention of epidemic recurrence and the protection of public health security in society. This article summarizes the latest developments in the research on transmission hosts of SARS-CoV-2, and makes the inference of potentially-multiple transmission hosts based on the facts from current epidemic. Therefore, it is vital to strengthen the construction of the integrated prevention-and-control system (with human and veterinary medicines) using the innovative One Health approach during the current epidemic prevention and control stage, as well as emerging epidemic in the future.

Key words: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), bat, intermediate host, One Health