上海交通大学学报（医学版）

›› 2009, Vol. 29 ›› Issue (9): 1074-.

• 论著（临床研究） • 上一篇    下一篇

思诺思对失眠症患者QUISI检测指标的影响

姚培芬1, 陈兴时1, 朱贻盛2, 肖泽萍1, 郭晓莉2, 王继军1, 张明岛1, 楼翡璎1, 唐云翔1, 陈 冲1   

  1. 上海交通大学 1. 医学院上海市精神卫生中心, 上海 200030；2. 生命科学技术学院, 上海 200240
  • 出版日期:2009-09-25 发布日期:2009-09-29
  • 通讯作者: 陈兴时, 电子信箱: chenxingshi2008@163.com。
  • 作者简介:姚培芬（1964—）, 女, 主任医师；电子信箱: ypf93@163.com。
  • 基金资助:

    上海市卫生局中医药科研基金（2008L036A）；上海交通大学“医工(理)交叉研究基金”（YG2007MS32）；国家高技术研究发展计划（“863”计划）（2007AA02Z420, 2008AA02Z412）；上海市市级医院新兴前沿技术联合攻关项目（SHDC12006105）

Effects of Stilnox on QUISI parameters in patients with insomnia

YAO Pei-fen1, CHEN Xing-shi1, ZHU Yi-sheng2, XIAO Ze-ping1, GUO Xiao-li2, WANG Ji-jun1, ZHANG Ming-dao1, LOU Fei-ying1, TANG Yun-xiang1, CHEN Chong1   

  1. 1. Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China；2. College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240, China
  • Online:2009-09-25 Published:2009-09-29
  • Supported by:

    Shanghai Municipal Health Bureau Foundation,2008L036A；Medicine and Industry Project from Shanghai Jiaotong University, YG2007MS32；National High Technology Research and Development Program of China, “863” Program, 2007AA02Z420, 2008AA02Z412；Joint Key Project of New Frontier Technology in Shanghai Municipal Hospitals, SHDC12006105

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摘要：

目的 应用QUISI仪检测思诺思对失眠症患者睡眠脑电活动的影响。方法 对32例失眠症患者进行连续3夜的QUISI描记，其中第3晚睡前30 min给予10 mg思诺思，观察用药后QUISI指标的变化。另设正常对照者28名，进行1夜适应和1夜基础QUISI监测。结果 失眠症组患者服用思诺思前夜间QUISI检测指标与正常对照组比较差异均有统计学意义（P<0.05或P<0.01）。失眠症组患者服用思诺思后，夜间QUISI检测显示睡眠效率提高，服药前和服药后睡眠效率为（87.7±7.3）% vs（91.4±3.8）%；醒觉时间为（40.5±15.5）min vs（22.1±6.1）min；S1为（29.9±18.3）％ vs （16.1±6.5）％；S2为（43.9±17.3）％ vs（59.1±4.7）％；睡眠潜伏期为（35.7±17.0）min vs（21.1±11.0）min（P<0.05或P<0.01）。结论 思诺思不仅能改善患者对睡眠的主观评价，还对夜间睡眠脑电有影响。

关键词: 失眠症, 思诺思, QUISI, 睡眠障碍

Abstract:

Objective To investigate the effects of Stilnox on brain electrical activity in patients with insomnia using QUISI sleep instrument. Methods QUISI sleep instrument was employed  for 32 patients with insomnia for 3 consecutive nights, among whom 10 mg Stilnox was administrated before sleep on the third night, and the changes of AUISI parameters were observed after Stilnox administration. Another 28 normal controls were selected, and received one night of acclimatization and the other night of baseline QUISI monitoring. Results There were significant differences in QUISI parameters between patients with insomnia and normal controls before Stilnox administration (P<0.05 or P<0.01). Compared with those before Stilnox administration, patients with insomnia had improved sleep efficiency [(87.7±7.3%)% vs (91.4±3.8)%], reduced awake time [(40.5±15.5) min vs (22.1±6.1) min], reduced S1 [(29.9±18.3)% vs （16.1±6.5）%], increased S2 [(43.9±17.3)% vs (59.1±4.7)%] and shortened sleep latency [(35.7±17.0)min vs （21.1±11.0）min] after Stilnox administration(P<0.05 or P<0.01). Conclusion Stilnox not only can improve the subjective evaluation on sleep, but also have effects on brain electrical activity in night in patients with insomnia.

Key words: insomnia, Stilnox, QUISI, sleep disorder

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