上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (1): 42-.

• 专题报道（营养学研究） • 上一篇    下一篇

恶性肿瘤患者能量代谢及相关机制的研究进展

黄翠花, 综述；蔡 威, 审校   

  1. 上海交通大学医学院 新华医院临床营养中心, 上海 200092
  • 出版日期:2010-01-26 发布日期:2010-01-26
  • 通讯作者: 蔡 威, 电子信箱: caiw204@yahoo.com.cn。
  • 作者简介:黄翠花（1983—）, 女, 硕士生；电子信箱: cuicui-2002@163.com。

Energy metabolism and related mechanism in patients with malignant tumors

HUANG Cui-hua, reviewer；CAI Wei, reviser   

  1. Clinical Nutrition Center, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China
  • Online:2010-01-26 Published:2010-01-26

PDF (PC)

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摘要：

能量代谢是指三大营养物质在体内代谢过程中伴随的能量产生和利用过程。肿瘤本身的作用、机体对肿瘤的反应以及抗肿瘤治疗使肿瘤患者的代谢具有特殊性。通常认为，初诊肿瘤患者的静息能量消耗增加，且与C反应蛋白和一些炎症细胞因子的释放相关；经有效治疗后，静息能量消耗则不同程度下降。肿瘤的分期及分化程度对机体代谢也有影响，但不同的研究结果存在矛盾。文章就肿瘤患者的能量代谢特点及相关影响因素进行综述。

关键词: 恶性肿瘤, 静息能量消耗, 炎症因子

Abstract:

Energy metabolism refers to the metabolism of three major nutrients associated with the process of energy production and usage. The metabolism in patients with tumors manifests specifically, as a result of tumor-bearing state, host's response to tumor and anti-neoplastic therapy. It is believed that resting energy expenditure increases in patients with newly diagnosed tumors, which is related to C-reactive protein and release of inflammatory cytokines. After effective therapy, resting energy expenditure decreases in some degree. In addition, the stage and differentiation of tumors also affect metabolism. However, there are some conflicts among research findings. The characteristics of energy metabolism and influential factors in patients with tumors are reviewed in this paper.

Key words: malignant tumor, resting energy expenditure, inflammatory cytokine