上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (2): 225-.

• 综述 • 上一篇    下一篇

经典Wnt信号通路与精神分裂症

王雪梅, 综述；崔东红, 肖泽萍, 审校   

  1. 上海交通大学 医学院精神卫生中心, 上海 200030
  • 出版日期:2010-02-25 发布日期:2010-02-25
  • 通讯作者: 崔东红, 电子信箱: manyucc@126.com。
  • 作者简介:王雪梅（1986—）, 女, 博士生；电子信箱: wangxuemei9966@163.com。
  • 基金资助:

    上海市市级医院新兴前沿技术联合攻关项目（SHDC12006105）；国家高技术研究发展计划(“八六三”计划)（2007AA02Z420）；上海市科委重点科技攻关项目（074119520）；上海市优秀学科带头人计划（08XD14036）；国家自然科学基金 (30670755)

Canonical Wnt pathway and schizophrenia

WANG Xue-mei, reviewer；CUI Dong-hong, XIAO Ze-ping, reviser   

  1. Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China
  • Online:2010-02-25 Published:2010-02-25
  • Supported by:

    Joint Key Project of New Frontier Technology in Shanghai Municipal Hospitals, SHDC12006105；Hi-Tech Research and Development Program of China, “863”Program, 2007AA02Z420；Shanghai Science and Technology Committee Foundation, 074119520；Program of Shanghai Subject Chief Scientist, 08XD14036；National Natural Science Foundation of China, 30670755

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摘要：

精神分裂症是一种重性精神病性障碍，病因和机制尚未明确，但目前普遍认为是由多个微效基因协同并与环境因素共同作用导致的疾病。由多基因组成的信号通路及通路间的相互作用在精神分裂症发病中可能起重要作用。与中枢神经系统发育和功能维持密切相关的经典Wnt信号通路近年来受到较多关注。许多针对Wnt信号通路与精神分裂症的关联研究均表明，精神分裂症患者细胞内Wnt信号通路异常。文章就目前针对经典Wnt信号通路在精神分裂症发病中潜在作用的相关研究作一综述。

关键词: 经典Wnt信号通路, 精神分裂症, 神经发育

Abstract:

Schizophrenia is one of the most severe psychiatric disorders. Although the etiology is unknown, schizophrenia appears to be a polygenic disorder associated with environmental factors. There are evidences that intracellular signaling plays an important role in the pathogenesis of schizophrenia. Canonical Wnt pathway, which is closely related to the development and function maintenance of central nervous system, have drawn wide attention. Evidences for potential disturbances of Wnt signaling pathways in schizophrenia have accumulated, which are in favour of the hypothesis that Wnt signaling alterations may be important in the pathogenesis of schizophrenia. The research advances in the relationship between canonical Wnt signaling pathway and schizophrenia are reviewed in this paper.

Key words: canonical Wnt pathway, schizophrenia, neurodevelopment