›› 2010, Vol. 30 ›› Issue (5): 500-.

• 专题报道(肾上腺疾病) • 上一篇    下一篇

肾上腺大结节样增生一例报道

周薇薇1, 姜 蕾1, 苏颋为1, 蒋怡然1, 王毅峰1, 唐 欣1, 俞 放1, 祝 宇2, 孙福康2, 方文强3, 金晓龙4, 宁 光1, 王卫庆1   

  1. 上海交通大学 医学院瑞金医院 1.内分泌代谢病科 上海市内分泌代谢病研究所 上海市内分泌代谢病临床医学中心, 2. 泌尿外科, 3. 放射科, 4. 病理科, 上海 200025
  • 出版日期:2010-05-25 发布日期:2010-05-28
  • 通讯作者: 王卫庆, 电子信箱: wqingw@hotmail.com。
  • 作者简介:周薇薇(1981—), 女, 住院医师, 硕士生;电子信箱: autumn.harvest@163.com。

One case report of adrenocorticotrophic hormone independent macronodular adrenal hyperplasia

ZHOU Wei-wei1, JIANG Lei1, SU Ting-wei1, JIANG Yi-ran1, WANG Yi-feng1, TANG Xin1, YU Fang1, ZHU Yu2, SUN Fu-kang2, FANG Wen-qiang3, JIN Xiao-long4, NING Guang1, WANG Wei-qing1   

  1. 1.Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, 2.Department of Urology, 3.Department of Radiology, 4.Department of Pathology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2010-05-25 Published:2010-05-28

摘要:

库欣综合征(CS)中15%~20%是由肾上腺原因引起的,其中约10%的患者具有双侧肾上腺增生。肾上腺性CS中皮质醇分泌有时可受肾上腺异常膜受体(包括抑胃肽受体、精氨酸加压素受体、儿茶酚胺类受体、LH/hCG受体和5-羟色胺受体等)的调节。该文报道了1例促肾上腺皮质激素非依赖性大结节样肾上腺增生引起的CS患者,并通过体内试验证实了肾上腺异常膜受体的存在。

关键词: 库欣综合征, 促肾上腺皮质激素非依赖性大结节样肾上腺增生, 异常膜受体

Abstract:

Primary adrenal causes contribute to 15% to 20% of Cushing's syndrome, and bilateral adrenal hyperplasia was found in 10% of patients with Cushing's syndrome. Cortisol secretion in adrenal Cushing's syndrome can be regulated by the aberrant adrenal expression of receptors for gastric inhibitory polypeptide, vasopressin, catecholamines, luteinizing hormone/human choriogonadotropin (LH/hCG) and serotonin. In this paper, a case of Cushing's syndrome caused by adrenocorticotrophic hormone-independent macronodular adrenal hyperplasia is reported.

Key words: Cushing´s syndrome, adrenocorticotrophic hormone independent macronodular adrenal hyperplasia, aberrant membrane receptors