›› 2010, Vol. 30 ›› Issue (9): 1164-.doi: 10.3969/j.issn.1674-8115.2010.09.035

• 综述 • 上一篇    下一篇

脂联素血管保护机制研究进展

张凌娟, 综述;苏 青, 审校   

  1. 上海交通大学 |医学院附属新华医院内分泌科, 上海 200092
  • 出版日期:2010-09-25 发布日期:2010-09-27
  • 通讯作者: 苏 青, 电子信箱: dr_suqing@yahoo.com.cn。
  • 作者简介:张凌娟(1983—), 女, 博士生;电子信箱: zhang.lingjuan@yahoo.com.cn。

Research progress of vascular protection mechanism of adiponectin

ZHANG Ling-juan, reviewer;SU Qing, reviser   

  1. Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2010-09-25 Published:2010-09-27

摘要:

脂联素是一种由脂肪细胞分泌的血浆蛋白,具有心血管保护作用。脂联素通过多种信号通路,发挥抗炎、抗氧化、抗动脉粥样硬化、改善微循环及双向调节血管新生的作用。文章就脂联素血管保护机制的研究进展作一综述。

关键词: 脂联素, 动脉粥样硬化, 信号通路

Abstract:

Adiponectin is an abundant plasma protein secreted from adipocytes that elicits protective effects in the vasculature and myocardium. Adiponectin suppresses oxidative stress, inhibits inflammatory signaling cascades, ameliorates microvascular circulation and regulates angiogenesis via multiple signal pathways. The research progress of vascular protection mechanism of adiponectin is reviewed in this paper.

Key words: adiponectin, atherosclerosis, signal pathway