上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (5): 672-.doi: 10.3969/j.issn.1674-8115.2011.05.031

• 综述 • 上一篇    下一篇

前列腺癌易感基因及遗传流行病学研究进展

吴琪俊1, 徐剑锋2, 施 榕1   

  1. 1.上海交通大学 公共卫生学院, 上海 200025； 2.复旦－VARI遗传流行病学研究中心, 上海 200433
  • 出版日期:2011-05-28 发布日期:2011-05-27
  • 通讯作者: 施 榕, 电子信箱: shirong61@yahoo.com.cn。
  • 作者简介:吴琪俊（1985—）, 男, 硕士；电子信箱: wuqijun111@sina.com。

Research progress of susceptible genes and genetic epidemiology of prostate cancer

WU Qi-jun1, XU Jian-feng2, SHI Rong1   

  1. 1.School of Public Health, Shanghai Jiaotong University, Shanghai 200025, China； 2.Fudan-VARI Genetic Epidemiology Research Centre, Fudan University, Shanghai 200433, China
  • Online:2011-05-28 Published:2011-05-27

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摘要：

遗传学研究证实遗传因素在前列腺癌的发展过程中具有一定的作用。同时，一些病例对照研究与基于人群的队列研究也提示前列腺癌具有复杂的遗传流行病学的特征。文章分析了流行病学暴露因素及易感基因与前列腺癌的关系，并就国内外前列腺癌遗传流行病学方面的研究现状以及今后研究的发展方向作一综述。

关键词: 前列腺癌, 易感基因, 全基因组关联研究, 单核苷酸多态性, 遗传流行病学

Abstract:

Many genetic researches have suggested that genetic factor plays an important role in the development of prostate cancer. Meanwhile, some case-control studies and population-based cohort studies have also revealed the complex genetic epidemiology characters of prostate cancer. This paper not only analyses the relationship between epidemic exposure factors, susceptible genes and prostate cancer, but also points out the present status of genetic epidemiology of prostate cancer and the prospects of research in this aspect.

Key words: prostate cancer, susceptible gene, genome-wide association study, single nucleotide polymorphisms, genetic epidemiology