上海交通大学学报（医学版）

›› 2013, Vol. 33 ›› Issue (5): 690-.doi: 10.3969/j.issn.1674-8115.2013.05.037

• 综述 • 上一篇    下一篇

影响奥氮平诱导的代谢紊乱动物模型可重复性的因素

张成芳1, Dake Qi2, 崔东红1   

  1. 1.上海交通大学 医学院附属精神卫生中心, 上海 200030； 2.耶鲁大学医学院内科, 纽黑文 06520
  • 出版日期:2013-05-28 发布日期:2013-05-28
  • 通讯作者: 崔东红, 电子信箱: donghong.cui@gmail.com。
  • 作者简介:张成芳（1987—）, 女, 硕士生； 电子信箱: callup1987@126.com。
  • 基金资助:

    上海市浦江人才计划（10PJ1408800）；国家自然科学基金（81171266）；上海市科技创新计划（11140900400）；教育部第43批留学回国人员科研启动基金；上海市公共卫生优秀学科带头人培养计划（GWDTR201230）；国家自然科学基金（81271481）

Influencing factors of reproducibility on establishment of Olanzapine-induced metabolic disorder animal model

ZHANG Cheng-fang1, Dake Qi2, CUI Dong-hong1   

  1. 1.Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China； 2.Department of Internal Medicine, Yale University School of Medicine, New Haven 06520, USA
  • Online:2013-05-28 Published:2013-05-28
  • Supported by:

    Shanghai Pujiang Talent Program, 10PJ1408800； National Natural Science Foundation, 81171266； Shanghai Science and Technology Innovation Program, 11140900400； Foundation of the Ministry of Education of China for Returned Talents from Overseas； Shanghai Public Health Excellent Discipline Leader Program, GWDTR201230； National Natural Science Foundation of China, 81271481

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摘要：

新型抗精神病药物奥氮平引起的代谢紊乱倍受瞩目,但机制未明，建立合适的动物模型是研究其不良反应机制的重要方法，而动物模型的稳定性和可重复性十分关键。文章对近年来奥氮平诱导的代谢紊乱的动物模型研究进行归纳，探讨了影响模型重复性的主要因素，旨在为相关研究提供参考。

关键词: 奥氮平, 代谢紊乱, 动物模型, 重复性

Abstract:

Olanzapine-induced metabolic disorders have been increasingly concerned. However, the mechanism is still unknown. The establishment of an appropriate animal model to explore the mechanism is a most important way, and the stability and reproducibility of an animal model are of vital importance. In this paper, the studies on establishment of Olanzapine-induced metabolic disorder animal models are reviewed, and the influencing factors of the reproducibility of animal models are discussed, hoping to provide reference for the related research.

Key words: Olanzapine, metabolic disorder, animal model, reproducibility