›› 2012, Vol. 32 ›› Issue (2): 214-.doi: 10.3969/j.issn.1674-8115.2012.02.020

• Review • Previous Articles     Next Articles

Research progress of antiangiogenic activity of tumstatin

MA Ying-yan, ZOU Hai-dong   

  1. Department of Ophthalmology, the First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China
  • Online:2012-02-28 Published:2012-02-28
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 11BA1409700；Shanghai Jiaotong University School of Medicine Foundation, 11XJ21056；Shanghai Key Laboratory for Ocular Fundus Diseases Foundation, 07Z22911

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Abstract:

Tumstatin is a bioactivator which can effectively suppress tumor growth by inhibiting both angiogenesis of tumor vessels and proliferation of tumor cells. Tumstatin has great ability to cause tumor stasis. The bioactivity and mechanisms  of tumstatin have been gradually revealed. The antiangiogenic activity and mechanisms of tumstatin are reviewed in this paper, and the prospect of application of tumstatin in ophthalmology is explored.

Key words: tumstatin, type Ⅳ collagen alpha3 chain, angiogenesis