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Correlation of IRS-1 gene between depression and accompanying anxiety symptoms

WANG Fan, ZHANG Chen, LI Ze-zhi, LI Hao-zhe, FANG Yi-ru   

  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine， Shanghai 200030， China
  • Online:2016-04-28 Published:2016-05-26
  • Supported by:

    National Natural Science Foundation of China， 91232719； National Key Clinical Disciplines—Shanghai Mental Health Center，2011-873； National Key Technology Research and Development Program of the Ministry of Science and Technology of China in the “12th Five-Year Plan”， 2012BAI01B04

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Abstract:

Objective To explore the correlation of the single nucleotide polymorphism in loci rs10178202 and rs2272205 of insulin receptor substrate 1 (IRS-1) gene with depression and accompanying anxiety symptoms. Methods Genome DNA of 585 Han patients with depression (case group) and 658 healthy controls (control group) were extracted. Genotypes in loci rs10178202 and rs2272205 of IRS-1 gene were detected by Taqman SNP genotyping technology. The difference in frequency distribution of genotypes between the case group and the control group was detected. Results The genotype distributions of two SNPs in two groups were consistent with the Hardy-Weinberg equilibrium. The differences in genotype and allele frequency in loci rs10178202 and rs2272205 between two groups were not statistically significant. The 7th factor of the HAMA scale was correlated with allele T in loci rs10708202 (OR=0.45, 95%CI 0.22-0.89, P=0.02). Both the 8th and 13th factors were correlated with age (OR=1.03, 95%CI 1.00-1.06, P=0.04; OR=1.03, 95%CI 1.00-1.06, P=0.04) and age was a risk factor of anxiety symptoms. Conclusion Loci rs10178202 and rs2272205 of IRS-1 gene are not significantly associated with depression, but may be associated with accompanying anxiety symptoms. Age is a risk factor of accompanying sensory system and autonomic nervous system symptoms.

Key words: depression, IRS-1, anxiety symptom, single nucleotide polymorphism, HAMA-14