An update about role of ovarian cancer-associated fibroblasts

doi:10.3969/j.issn.1674-8115.2016.08.026

• Review • Previous Articles Next Articles

An update about role of ovarian cancer-associated fibroblasts

BU Shi-xia, LAI Dong-mei

The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

Online:2016-08-29 Published:2016-08-31
Supported by:
Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support，20152236；Project of Shanghai Municipal Science and Technology Commission，14411961500；National Natural Science Foundation of China，81370678

Abstract

Abstract:

Epithelial ovarian cancer (EOC) remains the leading cause of gynecological cancer-related death. In the tumor microenvironment, the reciprocal inter-communication between ovarian cancer cells and ovarian cancer-associated fibroblasts (OCAFs) plays an important role in the progression of ovarian cancer. This review discusses the latest research progresses about OCAFs, including their possible origins, their effects on the progression of ovarian cancer, the potential diagnostic and predictive value of OCAFs, and the potential of OCAF-targeted therapy.

Key words: ovarian cancer, tumor microenvironment, cancer-associated fibroblasts

BU Shi-xia, LAI Dong-mei. An update about role of ovarian cancer-associated fibroblasts[J]. , doi: 10.3969/j.issn.1674-8115.2016.08.026.

[1]	Qi-sheng GU, Mi-li ZHANG, Can CAO, Ji-kun LI. Association of alternative splicing and tumor immune in gastric cancer based on TCGA data set [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(4): 448-458.
[2]	Yuan-xin HUANG, Dong-mei LAI. Application of proteomics to the study of gynecological diseases [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(2): 233-240.
[3]	Meng-ke LIU, Meng-meng JI, Lin CHENG, Jin-yan HUANG, Xiao-jian SUN, Wei-li ZHAO, Li WANG. Research progress in anti-tumor effect and mechanism of baicalin [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(2): 246-250.
[4]	GAO Jing-ze, WU Xia. CXCL9 mRNA in ovarian tumor tissue and its relations with prognosis and characteristics of immune microenvironment [J]. , 2020, 40(4): 457-.
[5]	PAN De-shen, LI Deng, SHAO Yi. Research progress on the promoting effect of interleukin-11 on tumors [J]. , 2020, 40(4): 548-.
[6]	ZHAO Wei-guang, LIU Zhi-hong. Advances in study of regulation of tumor immune inflammatory microenvironment by cancer-associated fibroblasts [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2020, 40(09): 1288-1293.
[7]	LIU Jie, QIU Xiao-chun. Research hotspots and trends of breast cancer stem cells [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2020, 40(07): 881-888.
[8]	LIANG Yu, JIANG Ming-jie, TIAN Ling. Advances in prostaglandin E2 reprogramming pancreatic cancer microenvironment [J]. , 2019, 39(8): 923-.
[9]	QIU Xing-di, WU An-yue, LI Dong, HONG Zu-bei, GU li-ying, QIU Li-hua. Mechanism of TWEAK promoting macrophage-derived exosomal miR-7 to epithelial ovarian cancer cell through regulating Dicer [J]. , 2018, 38(7): 740-.
[10]	XU Hua-li, LIU Wen-xue, SHEN Fang-qian, XI Xiao-wei. Effects of UBE3C on proliferation and invasion in ovarian cancer SKOV3 cells [J]. , 2018, 38(6): 610-.
[11]	CAI Liu-yun, LUO Xiao-dong, LIANG Hao, HU Jian-guo. Inhibition of C2CD3 regulates the proliferation, invasion and migration of epithelial ovarian cancer through inhibiting Hedgehog pathway [J]. , 2018, 38(12): 1414-.
[12]	TANG Zhong-yuan1, 2, ZHANG Ning2, 3, DI Wen2, 3, LI Wei-ping2, 3. Effect of 3-methyladenine on autophagy, migration and invasion in epithelial ovarian cancer cells under hypoxia [J]. , 2018, 38(10): 1152-.
[13]	LI Dong, HU Yuan, WU An-yue, QIU Xing-di, QIU Li-hua . Exosomal miRNA-7 from TWEAK-stimulated macrophages inhibiting the invasion and migration of ovarian cancer cells [J]. , 2017, 37(6): 726-.
[14]	GUO Bi-ying, YAN Huan, ZHANG Shu . Effects of CTHRC1 on human ovarian cancer cell metastasis and its mechanism [J]. , 2017, 37(04): 438-.
[15]	LONG Ying-fei, TANG Jun-ying. Effects of silencing FUNDC1 gene on proliferation and invasion of ovarian cancer cell SKOV3 [J]. , 2016, 36(02): 218-.

An update about role of ovarian cancer-associated fibroblasts

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

TrendMD

References

Related Articles 15

Recommended Articles

Metrics

Comments