›› 2018, Vol. 38 ›› Issue (4): 361-.doi: 10.3969/j.issn.1674-8115.2018.04.001

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Mechanism of Wdpcp in regulating coronary artery development

LIU Xiang-yang1, CAI Chen-leng2   

  1. 1. Shanghai Pediatric Congenital Heart Disease Institute, Pediatric Translational Medicine Institute, Shanghai Jiao Tong University School of Medicine, Shanghai Children’s Medical Center, Shanghai 200120;2. Riley Heart Research Center, Herman Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN46202, USA
  • Online:2018-04-28 Published:2018-05-03
  • Supported by:
    Key Program of the Ministry of Science and Technology, 2013CB945302;National Natural Science Foundation of China, 31371465, 31771612; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20171925;Shanghai Municipal Commission of Health and Family Planning Foundation, XBR2015

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Abstract: Wdpcp, a planar cell polarity (PCP) effector gene, plays essential roles in organogenesis during embryonic development through regulating collective cell movement and ciliogenesis. WDPCP mutations are associated with Bardet–Biedl syndrome and Meckel–Gruber syndrome in human. This study revealed a novel role of Wdpcp in regulating coronary artery development in mouse, demonstrating a new pathogenic phenotype associated with mutations of this gene in human. Results of this study may help us to understand the etiology of coronary artery disease.

Key words: Wdpcp gene, coronary artery development, epicardial derived cell, epithelial-mesenchymal transition

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