›› 2018, Vol. 38 ›› Issue (4): 477-.doi: 10.3969/j.issn.1674-8115.2018.04.024

• Review • Previous Articles     Next Articles

Effect of peroxisome proliferator-activated receptors in optic nerve protection

SHI Dan-li , WANG Ruo-bing, LIU Lin   

  1. Department of Ophthalmology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2018-04-28 Published:2018-05-03
  • Supported by:
    Research Project of Shanghai Municipal Commission of Health and Family Planning, M201440522

Abstract: Neuronal death is thought to be irreversible. In optic nerve-related diseases, the death and axonal loss of retinal ganglion cells could leadto irreversible visual impairment. A large number of studies support the hypothesis that the peroxisome proliferator-activated receptors (PPARs), onceactivatedparticular ligands, could have a potential neuroprotective effect on the peripheral organs and the central nervous system suffering acuteor chronic injury. Optic nerve belongs to the extension of white matter in the central nervous system and shares similar pathophysiological processes with the central nervous system, which makes PPARs a hot spot in the field of optic nerve protection. This paper reviewed the effect of PPARs in optic nerve protection and its possible mechanism.

Key words: peroxisome proliferator-activated receptors , optic nerve protection, retinal ganglion cells

CLC Number: