JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2020, Vol. 40 ›› Issue (12): 1632-1636.doi: 10.3969/j.issn.1674-8115.2020.12.011

• Original article (Clinical research) • Previous Articles     Next Articles

Expression of IL-1β, IL-6 and TNF-α in sulcular fluid of peri-implantitis

CHEN Hui-wen1, HU Yi 1, ZHANG Wei-ping2, CHEN Jing-yi2#, SONG Zhong-chen1#   

  1. 1. Department of Periodontology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China; 2. Stomatology Hospital of Lanzhou City, Gansu Province, Lanzhou 730000, China
  • Online:2020-12-28 Published:2021-02-02
  • Supported by:
    Lanzhou Talent Innovation Science and Technology Plan (2017-RC-12).

Abstract: Objective · To investigate expressions of interleukin (IL) -1β, IL-6 and tumor necrosis factor-α (TNF-α) in sulcular fluid of peri-implantitis. Methods · Twenty-four patients with implant restoration were selected, including 12 patients in the peri-implantitis group and 12 patients in the peri-implant health group. Twelve healthy persons with healthy gingival tissues were taken as the control group. The levels of IL-1β, IL-6 and TNF-α in gingival crevicular fluid were detected by enzyme-linked immunosorbent assay. The correlations between the expressions of these cytokines and the amount of gingival crevicular fluid or the probing depth were analyzed. Results · The levels of IL-1β, IL-6 and TNF-α in the peri-implantitis group were significantly higher than those in the control group (all P<0.05). The expression levels of IL-1β and IL-6 in the peri-implantitis group were significantly higher than those in the peri-implant health group (both P<0.05). The level of TNF-α in the peri-implantitis group was positively correlated with the probing depth (r=0.600, P=0.039). Conclusion · The levels of IL-1β, IL-6 and TNF-α in gingival crevicular fluid are highly expressed in patients with peri-implantitis. The expression of TNF-α is positively correlated with the probing depth.

Key words: peri-implantitis, gingival crevicular fluid, interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)

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