JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (2): 233-240.doi: 10.3969/j.issn.1674-8115.2021.02.017

• Review • Previous Articles     Next Articles

Application of proteomics to the study of gynecological diseases

Yuan-xin HUANG(), Dong-mei LAI()   

  1. Shanghai Key Laboratory of Embryo Original Diseases, The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Received:2020-07-30 Online:2021-02-28 Published:2021-02-28
  • Contact: Dong-mei LAI E-mail:sylviehyx@outlook.com;laidongmei@hotmail.com
  • Supported by:
    National Key Research and Development Project of China(2018YFC1004800);National Natural Science Foundation of China(81971334);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20152236)

Abstract:

At present, proteomics is one of the core contents of biomedical research. Its research includes the exploration of biological processes such as signal transduction, cell proliferation and differentiation, protein translation and modification, as well as the search for biomarkers and drug targets of diseases. This review summarizes the application of mass spectrometry-based proteomics to the studies of pathogenesis and biomarkers of common gynecological diseases, including polycystic ovary syndrome, premature ovarian insufficiency, ovarian cancer, endometrial cancer and cervical cancer.

Key words: proteomics, polycystic ovary syndrome, premature ovarian insufficiency, ovarian cancer, endometrial cancer, cervical cancer

CLC Number: