›› 2018, Vol. 38 ›› Issue (1): 48-.doi: 10.3969/j.issn.1674-8115.2018.01.015

• Original article (Basic research) • Previous Articles     Next Articles

Effects of GLP-1 analogues on kidney function and kidney ultrastructure in type 2 diabetic rats

SUI Chun-hua, LU Ying-li, GUO Yu-yu   

  1. Department of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011
  • Online:2018-01-28 Published:2018-03-09

Abstract: Objective · To study the effects of glucagon-like peptide-1(GLP-1) analogues on kidney function and kidney ultrastructure in type 2 diabetic
rats. Methods · Twenty-eight SPF level male SD rats were randomly divided into control groups (normal control group and diabetic control group) and
GLP-1 analogues Exenatide intervention groups(normal intervention group and diabetic intervention group). The effects of Exenatide intervention
on glucose, lipid metabolism, kidney function and kidney ultrastructure were observed. Results · Fasting glucose, fasting insulin, insulin sensitivity
index, insulin resistance index, lipid profile, 24-hours microalbuminuria, serum creatinine and blood urea nitrogen of Exenatide intervention group were
much better than those of corresponding control groups. Through electron microscopy, glomerular mesangial cell in diabetic control group proliferated,
basement membrane thickened, while glomerular mesangial cell in diabetic intervention group did not proliferate, basement membrane mildly thickened.
Conclusion · GLP-1 analogues can improve kidney function of diabetic rats. Maybe it is connected with improving kidney ultrastructure.

Key words: glucagon-like peptide-1 analogue, diabetes, glucose and lipid metabolism, kidney function, ultrastructure