›› 2011, Vol. 31 ›› Issue (5): 604-.doi: 10.3969/j.issn.1674-8115.2011.05.017

• Original article (Clinical research) • Previous Articles     Next Articles

Correlation of expression of IDO and FoxP3 with progression and prognosis of cervical cancer

GU Zhuo-wei1, DI Wen1, YE Wei-yi2, WANG Ying2   

  1. 1.Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China；2.Shanghai Institute of Immunology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2011-05-28 Published:2011-05-27
  • Supported by:

    Shanghai Education Committee Foundation, J50207

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Abstract:

Objective To investigate the correlation of expression of indoleamine 2,3-dioxygenase(IDO) and FoxP3 with progression and prognosis of cervical cancer. Methods Twenty cases of cervical intraepithelial neoplasia(CIN) Ⅰ-Ⅱ grade (CINⅠ-Ⅱ grade group), 20 cases of CIN Ⅲ grade (CIN Ⅲ grade group) and 60 cases of cervical cancer (cervical cancer group) were selected, and 20 cases of uterine myoma were served as control group. The expression of IDO and FoxP3 in CIN and cervical cancer lesions was detected by immunohistochemistry. Patients were followed up for prognostic indicators. Results The expression of IDO and FoxP3 in cervical cancer group was significantly higher than that in control group and CIN groups (P<0.01). In cervical cancer group, the expression of IDO was related to both FIGO stage and histological grade of cervical cancer (P<0.05), the expression of FoxP3 was related to FIGO stage (P<0.05), and the expression of IDO and FoxP3 in recurrence and death group was higher than that in survival group, with no significant difference between them (P>0.05). Conclusion The increased expression of IDO and FoxP3 in local lesions of cervical cancer is closely related to the occurrence and progression of the disease, which may serve as adjuvant indicators for screening, preoperative evaluation and postoperative follow-up of cervical cancer, as well as theory basis for therapeutic targets of cervical cancer.

Key words: cervical cancer, cervical intraepithelial neoplasia, indoleamine 2,3-dioxygenase, FoxP3