›› 2011, Vol. 31 ›› Issue (5): 663-.doi: 10.3969/j.issn.1674-8115.2011.05.029

• Review • Previous Articles     Next Articles

Research progress of Pax6 gene mutation and development of pancreas and diabetes mellitus

LU Yu-feng1,2, LIU Li-mei1   

  1. 1.Shanghai Diabetes Institute, Department of Endocrinology and Metabolism,the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China;2.Suzhou University, Suzhou 215006, China
  • Online:2011-05-28 Published:2011-05-27
  • Supported by:

    National Natural Science Foundation of China, 30771022;Shanghai Science and Technology Committee Foundation, 10XD1403400

Abstract:

Paired box 6(Pax6) is one of the members of Pax polygene transcription factor family, and plays an important role in the development of pancreas, α cell differentiation, transcription and activation of glucagon gene, β cell function and expression of insulin. Pax6 is the major gene in regulating the development of β cells, and its mutation contributes to the pathogenesis of impaired glucose tolerance and early-onset diabetes mellitus. The research progress of associations of Pax6 mutation with development of pancreas and diabetes mellitus is reviewed in this paper.

Key words: paired box 6 gene, mutation, pancreatic development, diabetes mellitus