›› 2011, Vol. 31 ›› Issue (7): 1022-.doi: 10.3969/j.issn.1674-8115.2011.07.034

• Review • Previous Articles     Next Articles

Interaction of long noncoding RNAs and other epigenetic mechanisms in tumors

SUN Tian-tian, FANG Jing-yuan   

  1. Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai 200001, China
  • Online:2011-07-28 Published:2011-07-27

Abstract:

As a newly discovered RNA interference method, long noncoding RNAs (lncRNA) play an important role in the development and progression of carcinomas, just as other epigenetic mechanisms including DNA methylation, histone modifications and chromatin remodeling. Recent researches have highlighted that lncRNA can interact with other epigenetic mechanisms. lncRNA can regulate DNA methylation, histone modifications, chromatin remodeling and other RNA interference through many ways, and the expression and role of lncRNA can be regulated by DNA methylation and chromatin remodeling. The complex relationship affects the development and progression of carcinomas.

Key words: long noncoding RNAs, epigenetics, tumor