›› 2011, Vol. 31 ›› Issue (12): 1729-.doi: 10.3969/j.issn.1674-8115.2011.12.015

• Original article (Clinical research) • Previous Articles     Next Articles

Efficacy and safety of budesonide suspension fluid combined with tulobuterol tape in treatment of recurrent wheezing in infants and young children

ZHU Ya-ju, LIN Qian, HUA Li, BAO Yi-xiao   

  1. Department of Pediatric Pneumology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2011-12-28 Published:2012-01-04
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 08411953200, 10DZ1951000

Abstract:

Objective To evaluate the efficacy and safety of budesonide suspension fluid inhalation combined with tulobuterol tape in treatment of recurrent wheezing in infants and young children. Methods Sixty-two infants and young children with recurrent wheezing were randomly divided into  treatment group (n=31) and control group (n=31). When wheezing was relieved, patients in  treatment  group were treated with budesonide suspension fluid inhalation combined with tulobuterol tape for 12 weeks, while those in control group were treated with  budesonide suspension fluid inhalation only. Patients were followed up during the 2nd, 4th, 6th, 8th, 10th and 12th week, and the frequencies of cough and respiratory tract infection and the condition of combination use of drugs were analysed. Results Thirty patients in  treatment group and 29 patients in control group completed the treatment and follow up. The scoring of cough, frequency of wheezing, scoring of wheezing and scoring of combination use of drugs in  treatment group were significantly lower than those in control group (P<0.01), and the frequency of respiratory tract infection in  treatment group was significantly lower than that in control group (P<0.05). Conclusion Budesonide suspension fluid inhalation combined with tulobuterol tape is more effective and safe than budesonide suspension fluid inhalation only in treatment of recurrent wheezing in infants and young children.

Key words: wheezing in infants and young children, tulobuterol tape, budesonide suspension fluid