%A Jiang YUE, Yong ZHOU, Hua XU, Wen LIU, Xiao-feng HAN, Qing MAO, Ji-dong ZHANG, Jing MA, Han-dong JIANG, Wei LIU %T Characteristic analysis and comparison of glycolipid metabolism in patients with coronavirus disease 2019 in common condition and severe cases %0 Journal Article %D 2021 %J Journal of Shanghai Jiao Tong University (Medical Science) %R 10.3969/j.issn.1674-8115.2021.03.012 %P 355-359 %V 41 %N 3 %U {https://xuebao.shsmu.edu.cn/CN/abstract/article_12937.shtml} %8 2021-03-28 %X Objective

·To analyze and compare the characteristics of glycolipid metabolism between common and severe patients with coronavirus disease 2019 (COVID-19).

Methods

·Thirty-six patients with COVID-19 were hospitalized in the general ward of Wuhan Leishenshan Hospital and fifty severe patients with COVID-19 in intensive care unit (ICU) from February to March, 2020. All the patients were divided into two groups: the common patient group and the severe patient group. Their electronic medical records were extracted and analyzed. The demographic data as well as clinical data, laboratory results, comorbidities and clinical outcomes in the two groups were collected and compared by independent sample t test, non-parametric test as well as χ2 test. From the metabolic point of view, the characteristics of glucose and lipid metabolism in COVID-19 common and severe patients and the possible related factors for patients staying in ICU were analyzed.

Results

·There was no significant difference between the two groups in terms of gender, number of patients with diabetes and coronary heart disease (CAD). The average age of severe patients was significantly older than that of the common patients (P<0.05). The proportion of the severe patients with hypertension (52.0%) was significantly higher than that of the common patients (22.2%) (P<0.05). The lymphocyte count of the severe patients was significantly lower than that of the common patients (P<0.05). There was no significant difference in glutamic-pyruvic transaminase (GPT), glutamic-oxaloacetic transaminase (GOT), serum creatinine (Scr) and blood uric acid (BUA) between the two groups. Blood serum albumin (ALB), adjusted calcium concentration (Cac), total cholesterol (TC), triacylglycerols (TAG), high density lipoprotein (HDL) and the low density lipoprotein (LDL) in the severe patients were significantly lower than those in the common patients (all P<0.05). Fasting blood glucose (FBG) in the severe patients was significantly higher than that in the common patients (P=0.001). Multivariate Logistic regression showed that the increase of FBG and the decrease of TC, HDL, LDL, ALB were related to COVID-19 patients staying in ICU.

Conclusion

·There are deteriorative disorders in terms of glucose and lipid metabolism among the severe patients with COVID-19. The FBG, TC, HDL, LDL and ALB may related to the admission of ICU.