上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (8): 894-.doi: 10.3969/j.issn.1674-8115.2010.08.006

• 论著（预防医学） • 上一篇    下一篇

先天性心脏病危险因素1∶1配对病例对照研究

芈 静1, 孟 灿2, 贾贤杰1, 张玉媛1   

  1. 1.蚌埠医学院预防医学系, 蚌埠 233000；2.复旦大学 公共卫生学院, 上海 200032
  • 出版日期:2010-08-25 发布日期:2010-08-27
  • 作者简介:芈 静（1976—）, 女, 讲师, 硕士生；电子信箱: xiaomi05011@sina.com。
  • 基金资助:

    安徽省教育厅自然科学基金（KJ2007B334ZC）和安徽省计生委基金（05-02）

1∶1 matched case-control study on risk factors of congenital heart diseases

MI Jing1, MENG Can2, JIA Xian-jie1, ZHANG Yu-yuan1   

  1. 1.Department of Preventive Medicine, Bengbu Medical College, Bengbu 233000, China；2.School of Public Health, Fudan University, Shanghai 200032, China
  • Online:2010-08-25 Published:2010-08-27
  • Supported by:

    Natural Science Foundation from the Department of Education, Anhui Province, KJ2007B334ZC；Foundation from Family Planning Committee of Anhui Province, 05-02

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摘要：

目的 探讨与先天性心脏病(CHD)发生有关的危险因素。方法 采用分层按比例整群抽样的方法，在安徽省蚌埠市16 698名0～5岁儿童中筛查出86例CHD患儿。采用1∶1配对病例对照研究方法，对照者为同性别、出生时间相差不超过1个月的健康儿童。采用单因素及多因素Logistic回归分析进行CHD的危险因素分析。结果 最终筛选出与CHD发生相关的4个危险因素，分别为母亲孕早期接触有毒化学物、孕早期呼吸道感染、有不良生育史、居住地附近有河流，其OR值分别为1.745、1.747、1.644和1.487。结论 母亲孕早期接触有毒化学物或发生呼吸道感染、有不良生育史、居住地附近有河流是新生儿CHD的主要危险因素。

关键词: 先天性心脏病, 危险因素, 病例对照研究

Abstract:

Objective To investigate the environmental risk factors associated with the development of congenital heart diseases (CHD). Methods Eighty-six children with CHD were screened from 16 698 children aged between 0 to 5 years in Bengbu, Anhui Province by stratified cluster sampling. A population-based 1∶1 matched case-control study was conducted, and each case was matched with one normal control by gender and birth date (with difference no more than one month). The risk factors of CHD were analysed by univariate and multivariate Logistic regression analysis. Results Four risk factors were screened to be associated with the development of CHD, including maternal exposure to poisonous chemicals during first trimester of pregnancy (OR, 1.745), maternal respiratory infection during first trimester of pregnancy (OR, 1.747), abnormal childbearing history（OR, 1.644）and river around the dwelling place（OR, 1.487）. Conclusion Maternal exposure to poisonous chemicals and maternal respiratory infection during first trimester of pregnancy, as well as abnormal childbearing history and river around dwelling place are major environmental risk factors contributing to CHD in neonates.

Key words: congenital heart disease, risk factor, case-control study