上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (11): 1401-.doi: 10.3969/j.issn.1674-8115.2010.11.020

• 论著（临床研究） • 上一篇    下一篇

子宫内膜异位症和（或）子宫腺肌症与面部色素斑发生的关系

夏丽群, 牛志宏, 冯 云   

  1. 上海交通大学 医学院附属瑞金医院生殖医学中心, 上海 |200025
  • 出版日期:2010-11-25 发布日期:2010-11-29
  • 通讯作者: 冯 云, 电子信箱: artruijin@yahoo.com。
  • 作者简介:夏丽群（1982—）, 女, 硕士生；电子信箱: xialiqun123@yahoo.cn。

Relationship between endometriosis and/or adenomyosis and incidence of facial melanin pigment

XIA Li-qun, NIU Zhi-hong, FENG Yun   

  1. Reproductive Medical Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2010-11-25 Published:2010-11-29

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摘要：

目的 研究子宫内膜异位症（简称内异症）和（或）子宫腺肌症（腺肌症）不孕与患者面部色素斑发生的关系，初步探讨内异症和（或）腺肌症表型特征及可能机制。方法 选择150例内异症和（或）腺肌症相关不孕患者及200例非内异症或腺肌症不孕患者作为研究对象，分别设为内异症和（或）腺肌症组和对照组。分析两组患者年龄、体质量指数(BMI)、血清基础雌二醇(E2)水平及面部色素斑发生情况（阳性率）；比较内异症和（或）腺肌症组内面部色素斑阳性与阴性者的血清基础E2、癌抗原125(CA125)水平和抗子宫内膜抗体(AEmAb)阳性率。结果 内异症和（或）腺肌症组患者面部色素斑阳性率明显高于对照组（47.33% vs 19.00%）(P<0.05）； 内异症和（或）腺肌症组各年龄段患者面部色素斑阳性率均显著高于对照组（P<0.05）；两组患者年龄、BMI、血清基础E2水平比较差异均无统计学意义（P>0.05）。内异症和（或）腺肌症组中面部色素斑阳性者与阴性者比较，血清基础E2和CA125水平以及AEmAb阳性率略有升高，但差异均无统计学意义（P>0.05）。结论 内异症和（或）腺肌症与患者面部色素斑产生有一定关系，但是否独立于体内基础雌激素并反映内异症和（或）腺肌症的病情程度，尚有待于进一步探讨。

关键词: 子宫内膜异位症, 子宫腺肌症, 面部色素斑, 色素沉着

Abstract:

Objective To investigate the relationship between endometriosis and/or adenomyosis-related infertility and facial melanin pigment, and explore the phenotypic characteristics and possible mechanism of endometriosis and/or adenomyosis. Methods One hundred and fifty infertile women with endometriosis and/or adenomyosis (endometriosis and/or adenomyosis group) and two hundred infertile women without endometriosis and/or adenomyosis (control group) were selected. The age, body mass index (BMI), serum basic estradiol (E2) level and incidence of facial melanin pigment (positive rates) of two groups were analysed, and the serum E2 level, cancer antigen 125 (CA125) level and positive rates of anti-endometrial antibody (AEmAb) were compared between patients with positive facial melanin pigment and those with negative facial melanin pigment in endometriosis and/or adenomyosis group. Results The positive rate of facial melanin pigment of endometriosis and/or adenomyosis group was significantly higher than that in control group (47.33% vs 19.00%)(P<0.05). The positive rates of facial melanin pigment of patients of different age stages in endometriosis and/or adenomyosis group were significantly higher than those in control group (P<0.05). There was no significant difference in age, BMI and serum basic E2 level between two groups (P>0.05). The serum basic E2 level, CA125 level and positive rate of AEmAb of endometriosis and/or adenomyosis group were higher than those in control group, with no significant difference between two groups (P>0.05). Conclusion Endometriosis and/or adenomyosis may be related to facial melanin pigment. Whether facial melanin pigment is independent of basic estrogen level and reflects the condition of endometriosis and/or adenomyosis needs to be further studied.

Key words: endometriosis, adenomyosis, facial melanin pigment, hyperpigmentation