上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (3): 263-.doi: 10.3969/j.issn.1674-8115.2012.03.006

• 论著（基础研究） • 上一篇    下一篇

股骨生长过程中的拓扑形状及骨质层变化机制研究

艾克然木·马合木提1, 买买提明·艾尼1, 居来提·买提肉孜1, 买买提江·马木提1, 张 瑞2, 买买提吐逊·吐尔地3   

  1. 1.新疆大学机械工程学院, 乌鲁木齐 830047； 2.新疆医科大学第六附属医院CT室, 乌鲁木齐 830054； 3.新疆医科大学第一附属医院口腔颌面外科, 乌鲁木齐 830054
  • 出版日期:2012-03-28 发布日期:2012-03-28
  • 通讯作者: 买买提明·艾尼, 电子信箱: mgheni@263.net。
  • 作者简介:艾克然木·马合木提(1984—), 男, 维吾尔族, 硕士生；电子信箱: akram1207@126.com。
  • 基金资助:

    国家自然科学基金(50775193, 50805125, 81160542）；新疆维吾尔自治区科技厅基金（201123113）；青年教师科研培育基金(XJED2009S55)

Topology shape and mechanism of variation of bone layer during growing process of femur

Aikeranmu Mahemuti1, Mamtimin Geni1, Julaiti Maitirouzi1, Maimaitijiang Mamuti1, ZHANG Rui2, Maimaitituxun3   

  1. 1.School of Mechanical Engineering, Xinjiang University, Urumqi 830047, China；2.Department of CT, the Sixth Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China；3.Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China
  • Online:2012-03-28 Published:2012-03-28
  • Supported by:

    National Natural Science Foundation of China, 50775193, 50805125, 81160542；Foundation of Department of Science and Technology, Xinjiang Uygur Autonomous Region, 201123113；Scientific Research Foundation for Culture of Young Teachers, XJED2009S55

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摘要：

目的 研究从胚胎期到成熟过程中股骨形成、生长和成形规律，分析骨生长中心形成、骨质层体积及骨形变化规律。方法 采用CT扫描技术定期扫描新西兰兔股骨生长过程并获取图像信息，用Mimics医学图像处理软件分析CT扫描断层图像信息。利用骨元体积法对股骨成形及其骨质层的变化过程进行时间分段和空间分层分析，分析股骨形成过程及骨质层体积变化规律。结果 股骨有多个骨生长中心。胚胎里股骨最早以软质骨的形式出现，随着生长逐渐硬化形成密质骨和硬质骨，最后形成最佳的股骨形状和骨质分布。结论 股骨由独立的4个骨生长中心发育并组合而成；各骨质层在生长过程中存在明显的体积和位置变化，但最终趋于稳定状态。

关键词: 股骨, 生长与发育, 骨质层, 骨生长中心

Abstract:

Objective To observe the rule of formation, growth and figuration of femur in the process from embryonic development to maturation, and analyse the formation of bone growth center, volume of bone layer and variation of bone shape. Methods CT scan technology was employed to obtain the imaging information of femur development process of rabbits, and the CT imaging information was processed with Mimics Medical Image Processing software. Time-phase and stratified space analysis of rule of femur figuration and variation of volume of bone layer were performed with unit bone volume method. Results Femur has multiple bone growth centers. The femur bone first emerged as spongy bone during embryonic process, and gradually got harden and formed the compact bone and enamel bone along with the growth. Finally, the femur bone developed its optimal shape and bone mass distribution. Conclusion The femur is developed by combination of 4 independent bone growth centers. There is obvious change in volume of bone layer and position in the process of bone growth, while stabilized state is eventually arrived.

Key words: femur, growth and development, bone layer, bone growth center