上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (7): 926-.doi: 10.3969/j.issn.1674-8115.2012.07.022

• 论著（临床研究） • 上一篇    下一篇

帕金森病患者伴疲劳症状的调查分析

董 青, 王智樱, 沈 沸, 杜芸兰, 俞 羚, 李焰生   

  1. 上海交通大学 医学院附属仁济医院神经内科, 上海 200127
  • 出版日期:2012-07-28 发布日期:2012-08-17
  • 通讯作者: 李焰生, 电子信箱: lliyans@hotmail.com。
  • 作者简介:董 青（1969—）, 男, 副主任医师, 硕士；电子信箱: dnqn1969@hotmail.com。

Study on fatigue in patients with Parkinson´s disease

DONG Qing, WANG Zhi-ying, SHEN Fei, DU Yun-lan, YU Ling, LI Yan-sheng   

  1. Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2012-07-28 Published:2012-08-17

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摘要：

目的 对帕金森病（PD）患者伴有疲劳症状的发生率进行横断面调查并分析相关危险因素。方法 应用疲劳严重度量表（FSS）评估234例非痴呆PD患者的疲劳程度，并分为疲劳组和非疲劳组。对两组患者进行统一PD评分量表（UPDRS）、Hoehn-Yahr（H-Y）分级、简易精神状态检查（MMSE）、17项汉密尔顿抑郁量表（HDRS）、PD睡眠量表（PDSS）和39项PD问卷（PDQ-39）测评。采用多因素Logistic回归分析PD患者疲劳的独立危险因素。结果 100例（42.7%）PD患者伴疲劳（FSS>4），排除抑郁障碍或睡眠障碍后仍有67例（34.9%）患者伴疲劳。疲劳组PDQ-39综合指数（PDQ-39SI）明显高于非疲劳组（Z=－8.066，P<0.01）。Logistic回归分析表明HDRS评分（OR=1.105，P=0.001）和PDSS评分（OR=0.967，P=0.000）是PD患者疲劳的独立危险因素。结论 疲劳是PD患者的常见症状和内在特征，严重影响患者的生活质量。改善抑郁症状和睡眠障碍症状可能缓解PD伴发的疲劳。

关键词: 帕金森病, 疲劳, 抑郁, 睡眠障碍

Abstract:

Objective To investigate the prevalence of fatigue symptom with cross-sectional survey, and analyse its risk factors in patients with Parkinson´s disease (PD). Methods Fatigue symptom was measured by Fatigue Severity Scale (FSS) in 234 non-dementia patients with PD, who were divided into fatigue group and non-fatigue group. All patients were assessed by the Unified Parkinson´s Disease Rating Scale (UPDRS), Hoehn-Yahr (H-Y) stage, Mini-Mental Status Examination (MMSE), Hamilton Depression Scale (HDRS)-17, Parkinson´s Disease Sleep Scale (PDSS) and Parkinson´s Disease Questionnaire-39 (PDQ-39). Multivariate Logistic regression analysis was performed to explore the independent risk factors of fatigue in patients with PD. Results One hundred patients (42.7%) had fatigue symptom (FSS>4), and 67 patients (34.9%) without major depression or sleep disturbance also reported fatigue. Patients in fatigue group had significantly higher score of the PDQ-39 summary index (PDQ-39SI) than those in non-fatigue group (Z=-8.066, P<0.01). Logistic regression analysis indicated that HDRS score (OR=1.105, P=0.001) and PDSS score (OR=0.967, P=0.000) were independent risk factors of fatigue in patients with PD. Conclusion Fatigue is a common symptom and intrinsic characteristic of patients with PD, which is closely related to the impaired quality of life. Control of depression and sleep disturbance may decrease the fatigue in patients with PD.

Key words: Parkinson´s disease, fatigue, depression, sleep disturbance