上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (10): 1334-.doi: 10.3969/j.issn.1674-8115.2012.10.012

• 论著（临床研究） • 上一篇    下一篇

抑郁症患者表情刺激视觉P300研究

朱 益, 陈兴时, 仇剑崟   

  1. 上海交通大学 医学院附属精神卫生中心心身科, 上海 200030
  • 出版日期:2012-10-28 发布日期:2012-11-05
  • 通讯作者: 仇剑崟, 电子信箱: jianyin_qiu@yahoo.com.cn。
  • 作者简介:朱 益（1977—）, 男, 主治医师, 硕士；电子信箱: zhuyi58@163.com。
  • 基金资助:

    上海市精神卫生中心院级科研基金项目（08-24）

Study on visual P300 evoked by facial expression stimulus in patients with depression

ZHU Yi, CHEN Xing-shi, QIU Jian-yin   

  1. Department of Psychosomatic Medicine, Shanghai Mental Health Center, Shang Jiaotong University School of Medicine, Shanghai 200030, China
  • Online:2012-10-28 Published:2012-11-05
  • Supported by:

    Shanghai Mental Health Center Foundation, 08-24

PDF (PC)

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摘要：

目的 探讨抑郁症患者由表情刺激所诱发的视觉P300的变化。方法 对30例抑郁症患者（抑郁症组）和30名正常对照者（正常对照组）进行自编社会人口学资料表及汉密尔顿抑郁量表(HAMD)评估，对两组进行由悲伤、高兴、惊讶、生气和厌恶五种表情刺激所诱发的视觉P300指标的检测和比较，对抑郁症组HAMD评分与视觉P300指标进行相关性分析。结果 抑郁症组悲伤表情诱发的靶P3潜伏期为（447.23±26.90）ms，高兴表情诱发的靶P3潜伏期为（444.40±28.52）ms，均较正常对照组显著延长（P<0.05）。抑郁症组HAMD评分与五种表情诱发的P300各指标之间无相关性（P＞0.05）。结论 抑郁症患者具有异常的由表情刺激诱发的视觉P300指标变化。

关键词: 抑郁症, 表情刺激, 视觉P300

Abstract:

Objective To investigate the changes of visual P300 evoked by facial expression stimulus in patients with depression. Methods Thirty patients with depression (depression group) and 30 normal controls (control group) were enrolled, and were evaluated by self-designed demographic questionnaire and Hamilton depression scale (HAMD). Besides, the examinations of visual P300 evoked by five facial expression stimulus, including depression, happiness, surprise, anger and disgust were conducted, and were compared between two groups. The correlation analysis of HAMD score with visual P300 was performed in depression group. Results The target P3 latency evoked by depression facial expression was (447.23±26.90) ms, that evoked by happiness facial expression was (444.40±28.52) ms, and both were significantly longer than those of control group (P<0.05). The HAMD score was not correlated with visual P300 evoked by facial expression stimulus in depression group (P＞0.05). Conclusion There are abnormal changes of visual P300 evoked by facial expression stimulus in patients with depression.

Key words: depression, facial expression stimulus, visual P300