上海交通大学学报（医学版）

上海交通大学学报（医学版）

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c-Met信号通路及其抑制剂的研究进展

舒孟军，郭圣荣   

  1. 上海交通大学 药学院, 上海 200240
  • 出版日期:2013-08-28 发布日期:2013-09-16
  • 通讯作者: 郭圣荣, 电子信箱: srguo@sjtu.edu.cn。
  • 作者简介:舒孟军（1984—）， 男， 硕士生; 电子信箱: mjshu@sjtu.edu.cn。

Research progress of c-Met signaling pathway and antagonists

SHU Meng-jun, GUO Sheng-rong   

  1. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China
  • Online:2013-08-28 Published:2013-09-16

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摘要：

c-Met和肝细胞生长因子（HGF）在很多肿瘤细胞组织中高表达。c-Met信号通路的活化引起一系列的信号级联放大反应，导致了肿瘤细胞的生长、增殖、侵袭和凋亡减少。HGF是c-Met的配体，参与并影响肿瘤微环境的形成。该文就HGF如何活化c-Met及其下游的信号通路、c-Met与其他受体介导的信号通路间的串话对耐药性的影响以及针对HGF和c-Met信号通路的抑制剂的研究进展进行综述。

关键词: c-Met, 肝细胞生长因子, c-Met抑制剂, 信号通路

Abstract:

High expression of c-MET and hepatocyte growth factor (HGF) is frequently found in tumor cells. The activation of c-Met signaling pathway triggers a series of signaling cascade reaction, leads to the growth, proliferation and invasion of tumor cells, and exempts tumor cells from apoptosis. HGF is the ligand of c-Met, and affects the formation of microenvironment of tumor cells. How HGF activates c-Met and the signaling pathway of its downstream components, and how the crosstalk of the signaling pathway mediated by c-Met and the other receptors affects the drug resistance are introduced in this paper. Besides, the research progress of HGF and c-Met signaling pathway inhibitors is also reviewed.

Key words: c-Met, hepatocyte growth factor, c-Met antagonists, signaling pathway