上海交通大学学报（医学版）

上海交通大学学报（医学版）

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黄曲霉毒素B1相关性肝细胞癌的分子流行病学研究

龙喜带1,2，姚金光2，黄小英2，黄炳臣2，王 超2，吴雪铭2，罗春英2，马 韵3，夏 强1   

  1. 1.上海交通大学 医学院附属仁济医院肝脏外科， 上海 200127； 2.右江民族医学院病理学教研室， 百色 533000； 3.广西医科大学病理学教研室， 南宁 533000
  • 出版日期:2013-09-28 发布日期:2013-09-29
  • 作者简介:龙喜带（1973—），男，博士，教授; 电子信箱: sjtulongxd@263.net。
  • 基金资助:

    国家自然科学基金（8116025）；上海市教委科研创新项目（13YZ035）；广西自然科学基金（0832097，2013GXNSFAA019251）；右江民族医学科研创新项目（2005，2008）

Molecular epidemiology studies on aflatoxin B1-related hepatocellular carcinoma

LONG Xi-dai1,2, YAO Jin-guang2, HUANG Xiao-ying2, HUANG Bing-chen2, WANG Chao2, WU Xue-ming2, LUO Chun-ying2, MA Yun3, XIA Qiang1   

  1. 1.Department of Liver Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China; 2.Department of Pathology, Youjiang Medical College for Nationalities, Baise 533000, China; 3.Department of Pathology, Guangxi Medical University, Nanning 533000, China
  • Online:2013-09-28 Published:2013-09-29
  • Supported by:

    National Natural Science Foundation of China, 8116025; Shanghai Education Committee Foundation, 13YZ035; National Natural Science Foundation of Guangxi, 0832097，2013GXNSFAA019251; Medical Innovation Project Foundation of Youjiang, 2005，2008

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摘要：

黄曲霉毒素B1（AFB1）是I类化学性致癌物，AFB1的高暴露是我国东南沿海一些地区肝细胞癌（HCC）高发的主要原因。因此，寻求有效的AFB1暴露水平的检测指标和筛选相应易感人群成为该研究领域关注的重要焦点。本课题组在AFB1相关性HCC研究领域中的关键热点如AFB1暴露信息评估、易感人群筛选及HCC发病风险与预后评估等进行了多项分子流行病学调查研究，研究结果显示：外周血AFB1-DNA加合物水平是一种有效的评估AFB1暴露水平的分子指标；DNA修复基因编码区突变增加HCC发病风险并影响预后。以上研究成果多次在国际肝脏病学与流行病学研究领域顶级杂志如Hepatology和Epidemiology等上报道，并获得一项省部级自然科学二等奖。

关键词: 肝细胞癌, 黄曲霉毒素B1, 分子流行病学

Abstract:

Aflatoxin B1 (AFB1) is an important chemical carcinogenic toxin, whose exposure is the main cause of hepatocellular carcinoma (HCC) in some southeast coastal zones in China. Thus, the majority of studies have been focused on seeking the evaluation methods of AFB1 exposure and screening susceptible population to AFB1-related HCC. We have investigated the following hot-spot issues: AFB1-exposure elucidation, susceptible population screen, and HCC risk and prognosis evaluation, using molecular epidemiology methods. Our data have shown that the AFB1-DNA level of peripheral blood leukocytes is an effective marker of AFB1exposure analysis, and the mutations at coding sequences of DNA repair genes increase HCC risk and modulate HCC prognosis. Through aforementioned projects, the corresponding results have been reported in the top-grade journals involved in liver and epidemiological fields, such as Hepatology and Epidemiology. Moreover, we have won the second prize of Provincial Natural and Science Award.

Key words: hepatocellular carcinoma, aflatoxin B1, molecular epidemiology