上海交通大学学报(医学版)

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载脂蛋白A-Ⅰ与多囊卵巢综合征关系的研究进展

仝腊娟,丘 彦   

  1. 重庆医科大学附属第一医院辅助生育中心, 重庆 400016
  • 出版日期:2013-11-28 发布日期:2013-12-03
  • 通讯作者: 丘 彦, 电子信箱: cqartq@163.com。
  • 作者简介:仝腊娟(1986—), 女, 硕士生; 电子信箱: tonglajuan@yahoo.cn。

Research advances in Apolipoprotein A-Ⅰ and polycystic ovary syndrome

TONG La-juan, QIU Yan   

  1. Department of Assistant Reproductive Centre, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China
  • Online:2013-11-28 Published:2013-12-03

摘要:

载脂蛋白A-Ⅰ(ApoA-Ⅰ)是参与胆固醇逆向转运(RCT)的重要因子,研究发现多囊卵巢综合征(PCOS)患者的ApoA-Ⅰ表达显著降低。ApoA-Ⅰ表达减少引起的胆固醇转运障碍,可能与PCOS患者的脂代谢异常和胰岛素抵抗等有关。

关键词: 载脂蛋白A-Ⅰ, 多囊卵巢综合征, 胆固醇逆向转运, 胰岛素抵抗

Abstract:

Apolipoprotein A-Ⅰ(ApoA-Ⅰ)is an important factor participating in the process of reverse cholesterol transport (RCT). In patients with polycystic ovary syndrome (PCOS), level of ApoA-Ⅰ was significantly low. The decreased expression of ApoA-Ⅰ could cause disorder of RCT, which may be connected with abnormal lipid metabolism and insulin resistance (IR) of PCOS patients.

Key words: apolipoprotein A-Ⅰ, polycystic ovary syndrome, reverse cholesterol transport, insulin resistance