上海交通大学学报（医学版）

上海交通大学学报（医学版）

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微RNA调控肿瘤多药耐药机制的研究进展

张平辰,盛小楠,林正钰,程雨龙,许伟榕   

  1. 上海交通大学  基础医学院细胞与分子生物学教学实验室， 上海 200025
  • 出版日期:2016-05-28 发布日期:2016-05-26
  • 通讯作者: 许伟榕, 电子信箱: xu_weirong@163.com。
  • 作者简介:张平辰(1994—)， 女， 临床八年制学生(法语班); 电子信箱: 496439458@qq.com。
  • 基金资助:

    上海交通大学医学院大学生创新训练计划(2014027)；国家级大学生创新创业训练计划(201510248065)

Research progresses of mechanisms for the regulation of tumor cell multi-drug resistance by miRNA

ZHANG Ping-chen, SHENG Xiao-nan, LIN Zheng-yu, CHENG Yu-long, XU Wei-rong   

  1. Laboratory for Cell and Molecular Biology， Basic Medicine Faculty of Shanghai Jiao Tong University， Shanghai 200025， China
  • Online:2016-05-28 Published:2016-05-26
  • Supported by:

    Undergraduate Innovation Training Program of Shanghai Jiao Tong University School of Medicine， 2014027； National Undergraduate Training Program for Innovation and Entrepreneurship, 201510248065

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摘要：

微RNA（miRNA）作为真核生物重要的基因表达调控分子，是肿瘤耐药调控机制中的重要构成部分。miRNA对靶基因的异常调控可以通过膜受体介导药物外排、药物靶点改变、细胞凋亡途径受阻、DNA修复能力改变等多种方式参与多药耐药调控机制。此外，miRNA调控肿瘤干细胞生长分化与通过激发保护性自噬来诱导多药耐药的研究领域也有重要进展。该文就miRNA调控肿瘤细胞多药耐药机制的研究进展作一综述。

关键词: 微RNA, 肿瘤；多药耐药

Abstract:

MicroRNA (miRNA) is a vital regulator for gene expression in eukaryotes, as well as an important component in the regulatory mechanism of tumor drug resistance. miRNA can abnormally regulate target genes through membrane receptor-mediated drug efflux, alteration of drug targets, block of cell apoptotic pathways, and change in DNA repair ability, etc., thus involving in the regulatory mechanism of multi-drug resistance. Important research advances in the regulation of growth and differentiation of cancer stem cells and the induction of multi-drug resistance via triggering the protective autophage by miRNA have been achieved. This paper reviews recent research progresses of mechanisms for the regulation of tumor cell multi-drug resistance by miRNAs.

Key words: microRNA, cancer, multidrug resistance