上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (12): 1677-1682.doi: 10.3969/j.issn.1674-8115.2020.12.020

• 综述 • 上一篇    下一篇

子宫内膜癌孕激素耐药机制及新型疗法的研究进展

沈 偲，滕银成   

  1. 上海交通大学附属第六人民医院妇产科，上海 200233
  • 出版日期:2020-12-28 发布日期:2021-02-02
  • 通讯作者: 滕银成，电子信箱：teng_yc@126.com。
  • 作者简介:沈 偲（1994—），女，博士生；电子信箱：shencai100@163.com。
  • 基金资助:
    国家自然科学基金（81974406）。

Research progress in progesterone resistance mechanism and novel treatment of endometrial cancer

SHEN Cai, TENG Yin-cheng   

  1. Department of Obstetrics and Gynecology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2020-12-28 Published:2021-02-02
  • Supported by:
    National Natural Science Foundation of China (81974406).

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摘要： 近年来我国子宫内膜癌发病率逐年上升，发病年轻化，早期子宫内膜癌的年轻患者保留生育功能的诉求日益强烈。目前孕激素治疗仍是保育治疗的首选，且已取得较好效果。但孕激素耐药和不良反应也成为部分患者孕激素治疗失败的主要原因。因此了解孕激素耐药机制及探究应对方法对于早期子宫内膜癌患者保育治疗具有指导意义。该文主要针对孕激素治疗发生耐药的机制、解决孕激素耐药的新型治疗方法（如宫腔镜）以及子宫内膜癌分子分型对预测孕激素耐药的指导意义进行综述。

关键词: 子宫内膜癌, 孕激素耐药, 保育治疗, 宫腔镜, 分子分型

Abstract:

The incidence of endometrial cancer among Chinese women has increased year by year with a younger trend in morbidity age. Young patients with early endometrial cancer are increasingly demanding fertility preservation. At present, progesterone therapy is still the first choice of fertility-sparing treatment, and has achieved good results. However, progesterone resistance and adverse reactions have also become the main reasons for the failure of progesterone therapy in some patients. Therefore, understanding the mechanism of progesterone resistance and exploring coping methods has guiding significance in the fertility-sparing treatment for early endometrial cancer patients. This article reviews the mechanism of progesterone resistance, the new treatment methods to solve progesterone resistance (such as hysteroscopy), and the significance of molecular typing of endometrial cancer in predicting progesterone resistance.

Key words: endometrial cancer (EC), progesterone resistance, fertility-sparing treatment, hysteroscopy, molecular typing

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