上海交通大学学报(医学版) ›› 2022, Vol. 42 ›› Issue (9): 1176-1181.doi: 10.3969/j.issn.1674-8115.2022.09.003

• 前沿述评 • 上一篇    

核酸适体药物偶联物——肿瘤精准治疗新风向

韩永琪1,2(), 韩达1, 閤谦1(), 姬丁坤1(), 谭蔚泓1()   

  1. 1.上海交通大学医学院附属仁济医院分子医学研究院,上海 200127
    2.上海师范大学化学与材料科学学院,上海 200234
  • 收稿日期:2022-05-18 接受日期:2022-08-18 出版日期:2022-09-28 发布日期:2022-09-28
  • 通讯作者: 閤谦,姬丁坤,谭蔚泓 E-mail:hjydyx413228@163.com;kara_xia@hotmail.com;dingkunji@sjtu.edu.cn;tan@hnu.edu.cn
  • 作者简介:韩永琪(1999—),男,硕士生;电子信箱:hjydyx413228@163.com
  • 基金资助:
    上海市自然科学基金面上项目(22ZR1437800);上海市青年科技英才扬帆计划(20YF1424500)

Aptamer-drug conjugates (ApDCs): new trend for cancer precision therapy

HAN Yongqi1,2(), HAN Da1, XIA Qian1(), JI Dingkun1(), TAN Weihong1()   

  1. 1.Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
    2.College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China
  • Received:2022-05-18 Accepted:2022-08-18 Online:2022-09-28 Published:2022-09-28
  • Contact: XIA Qian,JI Dingkun,TAN Weihong E-mail:hjydyx413228@163.com;kara_xia@hotmail.com;dingkunji@sjtu.edu.cn;tan@hnu.edu.cn
  • Supported by:
    Natural Science Foundation of Shanghai(22ZR1437800);Shanghai Sailing Program(20YF1424500)

摘要:

癌症严重威胁人类的生命健康,癌症的精准治疗至今仍是亟须解决的重大医学难题。精准分子医学,可从分子水平上诊断和治疗肿瘤,为肿瘤诊疗提供新的策略。作为优异的靶向识别分子和药物递送载体,核酸适体及核酸适体偶联物为肿瘤的精准治疗提供了重要的分子工具,已成为肿瘤靶向治疗的前沿新兴领域。该文综述了核酸适体性质及筛选技术、核酸适体药物偶联物的构建及其在临床肿瘤靶向治疗中的应用,并对核酸适体药物在肿瘤精准分子医学中的发展前景进行展望,以期为新型分子靶向药物的开发及其在临床恶性肿瘤治疗中的应用提供新的思路。

关键词: 分子医学, 核酸适体, 抗癌药物, 靶向治疗

Abstract:

Cancer is a worldwide medical issue that seriously threatens human health. Precision molecular medicine provides a new strategy for cancer theranostics. As excellent targeting recognition molecules and drug delivery platforms, aptamers and aptamer drug-conjugates (ApDCs) have provided a series of useful molecular tools for cancer precision therapy. In this paper, the properties and the selection techniques of aptamers, the construction of ApDCs and their applications to clinical tumor-targeting therapy are reviewed. Additionally, the challenges and perspective of ApDCs in precision molecular medicine for cancers are presented. This review may provide new horizons for molecular-targeted anti-tumor drugs in the therapy of clinical malignant tumors.

Key words: molecular medicine, aptamer, anti-cancer drug, targeted therapy

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