综述

无绿藻病研究新进展

  • 王影 ,
  • 刘锦燕 ,
  • 史册 ,
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  • 上海交通大学 医学院附属瑞金医院 1.检验科, 上海 200025; 2.卢湾分院放免检验科, 上海 200020
王影(1989—), 女, 硕士生; 电子信箱: sjdwangying@163.com。

网络出版日期: 2015-06-04

基金资助

上海市医学重点专科配套课题(ZK2012A21);黄浦区卫生局项目(2012-HGG-44)

Advances of protothecosis

  • WANG Ying ,
  • LIU Jin-yan ,
  • SHI Ce ,
  • et al
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  • 1.Department of Clinical Microbiology Laboratory, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2.Radioimmunology and Clinical Laboratory, Luwan Branch, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China

Online published: 2015-06-04

Supported by

Shanghai Key Specialty of Medicine Supporting Project, ZK2012A21; Huangpu District Health Bureau Foundation, 2012-HGG-44

摘要

无绿藻病是由条件致病菌无绿藻引起的一种较为罕见的疾病。近年来,随着免疫缺陷患者的增多,无绿藻病的发生率有上升趋势。无绿藻病以皮肤型多见,也可表现为鹰嘴滑囊及纤维组织感染或系统性感染。由于已报道的无绿藻病例数有限,其发病机制还不是很清楚,临床表现缺乏特异性,微生物学检查易被误认为酵母菌而漏检。为了提高对无绿藻病的认识,该文分析总结国内外已报道的无绿藻病,就其病因、发病机制、临床表现、诊断特征、治疗及预后等作一综述。

本文引用格式

王影 , 刘锦燕 , 史册 , . 无绿藻病研究新进展[J]. 上海交通大学学报(医学版), 2015 , 35(5) : 765 . DOI: 11.3969/j.issn.1674-8115.2015.05.027

Abstract

Protothecosis is a rare infection caused by members of genus Prototheca, which are opportunistic pathogens. Given the increasing number of immunocompromised individuals throughout the world, the incidence of protothecosis keeps increasing. The most common clinical manifestation of protothecosis is cutaneous protothecosis, as well as olecranon bursitis, fibrous tissue infection, and systemic infection. Because of the limited cases of protothecosis, the pathogenesis of protothecosis is largely unknown; the manifestations are lack of specificity; and it is commonly misidentified as the yeast in clinical laboratory. In order to improve the understanding of protothecosis, this paper reviews reported cases of protothecosis at home and abroad, and summarizes its etiology, pathogenesis, clinical manifestation, diagnostic features, treatment, and prognosis.
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