网络出版日期: 2016-01-21
Hydrochloric acid-induced acute respiratory distress syndrome: one case report
Online published: 2016-01-21
目的 探讨盐酸气体吸入引起的急性呼吸窘迫综合征(ARDS)临床特点及治疗方法。方法 报道1例双相水平气道正压通气(BIPAP)联合吡非尼酮(PFD)治疗盐酸气体吸入致ARDS患者的临床资料,复习文献探讨治疗特点。结果 男性患者,33岁,因吸入浓盐酸气体后出现咳嗽、咳痰伴胸闷、气促就诊。CT示两肺弥漫性改变,手指脉搏血氧饱和度75%,以“吸入性肺炎,ARDS”收治入院,经BIPAP辅助通气、PFD抗纤维化等治疗后患者氧合改善,临床症状好转,两肺纤维灶减少。结论 早期BIPAP的应用可以显著降低ARDS患者的插管率以及病死率。ARDS纤维化期予以PFD可以防止甚至逆转纤维化。
关键词: 双相水平气道正压通气; 吡非尼酮; 急性呼吸窘迫综合征
张丽妍 , 谭晓明 , 李燕芹 , 等 . 盐酸气体吸入致急性呼吸窘迫综合征1例报道[J]. 上海交通大学学报(医学版), 2015 , 35(12) : 1934 . DOI: 10.3969/j.issn.1674-8115.2015.12.034
Objective To explore the clincial characteristics and therapy of hydrochloric acid gas inhalation-induced acute respiratory distress syndrome (ARDS). Methods Clinical date of an ARDS following inhalation of hydrochloric acid gas treated by bilevel positive airway pressure (BIPAP) vetilation with pirfenidone (PFD) was reported. Literature was reviewed to investigate the treatment characteristics. Results A 33-year-old male patient was admitted to our department due to cough, expectoration, chest distress and shortness of breath after hydrochloric acid gas inhalation. Lung CT showed diffuse interstitial pulmonary damage. Oxygen saturation decreased to 75%. The patient was diagnosed as “aspiration pneumonia and ARDS”. The oxygenation and clinical symptoms were improved via BIPAP ventilation combined with PFD. The fibrous foci of two lungs reduced. Conclusion Early application of BIPAP can significantly reduce the intubation rate and mortality of ARDS. PFD can delay the process of pulmonary fibrosis, and even reversed.
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