综述

白假丝酵母菌唑类耐药相关的转录调控研究进展

  • 刘锦燕 ,
  • 史册 ,
  • 王影 ,
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  • 1.上海交通大学  医学院附属瑞金医院卢湾分院放免检验科, 上海 200020; 2.上海交通大学 医学院附属瑞金医院检验科, 上海 200025
刘锦燕(1981—), 女, 主管技师, 硕士; 电子信箱: stellaljy@163.com。

网络出版日期: 2016-03-29

基金资助

上海市重点专科配套课题(ZK2012A21);上海市科委基金(15ZR1426900);上海黄浦区卫生局基金(2012-HGG-44);上海市黄浦区卫生系统优秀青年人才培养计划(RCPY1407)

Research advances in transcription regulation related to azole resistance of Candida albicans

  • LIU Jin-yan ,
  • SHI Ce ,
  • WANG Ying ,
  • et al
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  • 1.Department of Clinical Laboratory, Luwan Branch, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China; 2.Department of Clinical Laboratory; Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Online published: 2016-03-29

Supported by

Project of Shanghai Key Specialty, ZK2012A21; Foundation of Shanghai Municipal Science and Technology Commission, 15ZR1426900; Foundation of Shanghai Municipal Huangpu District Health Bureau, 2012-HGG-44; Shanghai Municipal Huangpu District Health System Program for Youths, RCPY1407

摘要

近30年来,白假丝酵母菌已成为导致免疫功能低下患者发病和死亡最常见的条件致病性真菌。随着临床上唑类药物的频繁使用,耐药菌株不断被检出,其耐药机制研究也备受关注。近年来,其在转录调控水平的机制研究也取得了很大进展,明确了耐药相关编码基因的顺式作用元件和反式作用因子,并部分阐述了相应的作用机制。文章就白假丝酵母菌唑类药物耐药相关的转录调控研究进展作一综述。

本文引用格式

刘锦燕 , 史册 , 王影 , . 白假丝酵母菌唑类耐药相关的转录调控研究进展[J]. 上海交通大学学报(医学版), 2016 , 36(2) : 291 . DOI: 10.3969/j.issn.1674-8115.2016.02.027

Abstract

In recent 30 years, Candida albicans has become the most common opportunistic pathogen that causes the incidence and mortality of patients with low immunity. With the frequent use of azole antifungal drugs, azole-resistant strains are often detected. Studies on the mechanism of drug resistance have drawn more and more attention. In recent years, studies on the mechanism of transcriptional regulation have also made great progress. The cis-acting elements and trans-acting factors of the resistant-related encoding gene were identified and the acting mechanism was partially elucidated. In this paper, research advances in the transcription regulation related to azole resistance of Candida albicans are reviewed.

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