综述

ACE2/Apelin信号与动脉粥样硬化

  • 张振洲 ,
  • 宋蓓 ,
  • 钟久昌
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  • 上海交通大学 医学院附属瑞金医院医学基因组学国家重点实验室, 上海市高血压研究所, 上海 200025
张振洲(1988—), 男, 博士生; 电子信箱: zhangbochuan1227@163.com。

网络出版日期: 2016-07-25

基金资助

国家重大研究计划资助项目(91339108);国家重点基础研究发展计划(2014CB542300);国家自然科学基金 (81370362; 81170246);上海市卫生局科研课题(201440368)

ACE2/Apelin signaling and atherosclerosis

  • ZHANG Zhen-zhou ,
  • SONG Bei ,
  • ZHONG Jiu-chang
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  • State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Hypertension, Shanghai 200025, China

Online published: 2016-07-25

Supported by

National Major Research Plan Training Program, 91339108;  National Basic Research Program of China, 2014CB542300; National Natural Science Foundation of China, 81370362, 81170246; Scientific Research Project of Health Bureau of Shanghai, 201440368

摘要

动脉粥样硬化性疾病已成为人类死亡的首要病因。肾素血管紧张素系统是促进粥样硬化性心血管疾病的发生及发展的重要因素。研究表明ACE2/Apelin信号发挥心血管保护作用。文章就ACE2/Apelin信号研究新进展及其在动脉粥样硬化病程中的调控作用作一综述。

本文引用格式

张振洲 , 宋蓓 , 钟久昌 . ACE2/Apelin信号与动脉粥样硬化[J]. 上海交通大学学报(医学版), 2016 , 36(6) : 917 . DOI: 10.3969/j.issn.1674-8115.2016.06.026

Abstract

Atherosclerotic diseases have become the leading cause of human death. The renin-angiotensin system is an important factor for promoting the occurrence and development of atherosclerotic cardiovascular diseases. Studies have revealed that the ACE2/Apelin signaling plays a protective role in the cardiovascular system. This article reviews the latest research advances in ACE2/Apelin signaling and its regulatory role in atherosclerosis.

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